Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspective

Stefano Zaffagnini; Magali Cucchiarini; Laura De Girolamo; Peter Angele; Rui Luís Reis; Henning Madry; Carlotta Perucca Orfei; Johannes Zellner; Giuseppe Filardo

Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspective

Stefano Zaffagnini, Magali Cucchiarini, Laura De Girolamo, Peter Angele, Rui Luís Reis, Henning Madry, Carlotta Perucca Orfei, Johannes Zellner, Giuseppe Filardo

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].

Original language	English
Title of host publication	Surgery of the Meniscus
Publisher	Springer
Pages	559-575
Number of pages	17
Volume	58
ISBN (Print)	978-3-662-49188-
Publication status	Published - Mar 3 2016

Keywords

gene therapy
growth factors
Mesenchymal Cells

Cite this

Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspective. / Zaffagnini, Stefano; Cucchiarini, Magali; De Girolamo, Laura; Angele, Peter; Reis, Rui Luís; Madry, Henning; Perucca Orfei, Carlotta; Zellner, Johannes; Filardo, Giuseppe.

Surgery of the Meniscus. Vol. 58 Springer, 2016. p. 559-575.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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abstract = "Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].",

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AU - Zaffagnini, Stefano

AU - Cucchiarini, Magali

AU - De Girolamo, Laura

AU - Angele, Peter

AU - Reis, Rui Luís

AU - Madry, Henning

AU - Perucca Orfei, Carlotta

AU - Zellner, Johannes

AU - Filardo, Giuseppe

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N2 - Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].

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KW - growth factors

KW - Mesenchymal Cells

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M3 - Chapter (peer-reviewed)

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SP - 559

EP - 575

BT - Surgery of the Meniscus

PB - Springer

ER -

Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspective

Abstract

Keywords

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