Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspective

Stefano Zaffagnini, Magali Cucchiarini, Laura De Girolamo, Peter Angele, Rui Luís Reis, Henning Madry, Carlotta Perucca Orfei, Johannes Zellner, Giuseppe Filardo

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].
Original languageEnglish
Title of host publicationSurgery of the Meniscus
Number of pages17
ISBN (Print)978-3-662-49188-
Publication statusPublished - Mar 3 2016


  • gene therapy
  • growth factors
  • Mesenchymal Cells


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