Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans

G. Palù, A. Cavaggioni, P. Calvi, E. Franchin, M. Pizzato, R. Boschetto, C. Parolin, M. Chilosi, S. Ferrini, A. Zanusso, F. Colombo

Research output: Contribution to journalArticle

Abstract

Retrovirus-mediated gene therapy is a particularly attractive approach for glioblastoma multiforme (GBM), given the poor prognosis of this tumour and its localized proliferation in post-mitotic tissue. In this study we assessed, for the first time in humans, the therapeutic potential of a newly designed bicistronic Moloney vector (pLIL-2-TK), combining the expression of a suicide gene (thymidine kinase, tk) with an immunomodulatory gene (human interleukin 2, IL-2). Evidence of transgene activity in the treated tumours is presented.

Original languageEnglish
Pages (from-to)330-337
Number of pages8
JournalGene Therapy
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 1999

Keywords

  • Brain tumours
  • Gene therapy
  • Glioblastoma multiforme
  • Interleukin-2
  • Retroviral bicistronic vector
  • Thymidine kinase

ASJC Scopus subject areas

  • Genetics

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    Palù, G., Cavaggioni, A., Calvi, P., Franchin, E., Pizzato, M., Boschetto, R., Parolin, C., Chilosi, M., Ferrini, S., Zanusso, A., & Colombo, F. (1999). Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans. Gene Therapy, 6(3), 330-337. https://doi.org/10.1038/sj.gt.3300805