Gene transfer technology in therapy: Current applications and future goals

Gaetano Romand, Carmen Pacilio, Antonio Giordano

Research output: Contribution to journalArticlepeer-review


Gene therapy has attracted much interest since the first submissions of phase I clinical trials in the early 1990s, for the treatment of inherited genetic diseases. Preliminary results were very encouraging and prompted many investigators to submit protocols for phase I and phase II clinical trials for the treatment of inherited genetic diseases and cancer. The possible application of gene transfer technology to treat AIDS, cardiopathies, and neurologic diseases is under evaluation. Some viral vectors have already been used to deliver HIV-1 subunits to immunize volunteers who are participating in the AIDS vaccine programs in the USA. However, gene delivery systems still need to be optimized in order to achieve effective therapeutic interventions. The purpose of this review is to summarize the latest achievements in improving gene delivery systems, their current application in preclinical studies and in therapy, and the most pressing issues that must be addressed in the area of vector design.

Original languageEnglish
Pages (from-to)225-236
Number of pages12
JournalThe oncologist
Issue number4
Publication statusPublished - 1998


  • Adeno-associated virus
  • Adenovirus
  • Cationic liposomes
  • Clinical trials
  • Gene delivery systems in vivo or in vitro
  • Gene therapy
  • Retroviruses

ASJC Scopus subject areas

  • Cancer Research
  • Hematology


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