Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)

G. De Benedictis, L. Carotenuto, G. Carrieri, M. De Luca, E. Falcone, G. Rose, S. Cavalcanti, F. Corsonello, E. Feraco, G. Baggio, S. Bertolini, D. Mari, R. Mattace, A. I. Yashin, M. Bonafè, C. Franceschi

Research output: Contribution to journalArticle

Abstract

The possibility that four loci (REN, THO, PARP, SOD2) are associated with longevity was explored by comparing the genotypic pools of subjects older than 100 years with those of younger subjects matched for sex and geographic area (northern and southern Italy), The markers (all located within the respective gene) were HUMREN4; HUMTHO1; HUMPARP (gt)845nt; SOD2(C/T)(401nt). In order to reduce the number of genotypes, multiallelic polymorphisms were recoded as diallelic according to allele size and frequency patterns (small: S, and large: L, alleles). A significant loss of LL homozygous genotypes was found at the THO focus in male but not in female centenarians with respect to matched controls. On the other hand no significant difference was found between case/control genotypic frequencies at REN, PARP, SOD2 loci. The latter loci therefore do not affect inter-individual variability in life expectancy (at least in terms of qualitative variants associated with the tested markers). However, the data is consistent with an association between the THO locus and longevity.

Original languageEnglish
Pages (from-to)534-541
Number of pages8
JournalEuropean Journal of Human Genetics
Volume6
Issue number6
Publication statusPublished - Nov 1998

Keywords

  • Human longevity
  • PARP
  • REN
  • SOD2
  • THO

ASJC Scopus subject areas

  • Genetics(clinical)

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    De Benedictis, G., Carotenuto, L., Carrieri, G., De Luca, M., Falcone, E., Rose, G., Cavalcanti, S., Corsonello, F., Feraco, E., Baggio, G., Bertolini, S., Mari, D., Mattace, R., Yashin, A. I., Bonafè, M., & Franceschi, C. (1998). Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). European Journal of Human Genetics, 6(6), 534-541.