General issues on microbial translocation in HIV-infected patients

S. Novati, P. Sacchi, S. Cima, V. Zuccaro, P. Columpsi, L. Pagani, G. Filice, R. Bruno

Research output: Contribution to journalArticlepeer-review

Abstract

The lumen of the gastrointestinal tract is home to an enormous quantity of different bacterial species that thrive in an often symbiotic relationship with the host. It is the principal source of microbial products because of its massive bacterial load. Injury to the immune component of the gastrointestinal mucosal surface, along with damage to the intestinal epithelial microenvironment with its antimicrobial functions, may affect systemic immune activation during the chronic phase of HIV infection through the increased translocation of luminal microbial products. Moreover, microbial translocation, which is defined as "the passage of both viable and nonviable microbes and microbial products such as endotoxin across anatomically intact intestinal barrier", may be a fundamental mechanism through which HIV accelerates progression of chronic viral hepatitis. Improvements in the tools available to microbiota research, and especially advancement of our knowledge in this area may help us in controlling the evolution of HIV disease, although population complexity and diversity between individuals make this challenging.

Original languageEnglish
Pages (from-to)866-878
Number of pages13
JournalEuropean Review for Medical and Pharmacological Sciences
Volume19
Issue number5
Publication statusPublished - 2015

Keywords

  • Bacterial traslocation
  • Gut microbiota
  • HIV immunity
  • HIV infection
  • HIV-HCV coinfection
  • Lipopolisaccaride (LPS)
  • Liver fibrosis

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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