General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL

Claudia Fazi, Lydia Scarfò, Lorenza Pecciarini, Francesca Cottini, Antonis Dagklis, Agnieszka Janus, Anna Talarico, Cristina Scielzo, Cinzia Sala, Daniela Toniolo, Federico Caligaris-Cappio, Paolo Ghia

Research output: Contribution to journalArticle

Abstract

Monoclonal B-cell lymphocytosis (MBL) is classified as chronic lymphocytic leukemia (CLL)-like, atypical CLL, and CD5 -MBL. The number of B cells per microliter divides CLL-like MBL into MBL associated with lymphocytosis (usually detected in a clinical setting) and low-count MBL detected in the general population (usually identified during population screening). After a median follow-up of 34 months we reevaluated 76 low-count MBLs with 5-color flow cytometry: 90% of CLL-like MBL but only 44.4% atypical CLL and 66.7% CD5 - MBL persisted over time. Population-screening CLL-like MBL had no relevant cell count change, and none developed an overt leukemia. In 50% of the cases FISH showed CLL-related chromosomal abnormalities, including monoallelic or biallelic 13q deletions (43.8%), trisomy 12 (1 case), and 17p deletions (2 cases). The analysis of the T-cell receptor β (TRBV) chains repertoire showed the presence of monoclonal T-cell clones, especially among CD4 highCD8 low, CD8 highCD4 low T cells. TRBV2 and TRBV8 were the most frequently expressed genes. This study indicates that (1) the risk of progression into CLL for low-count population-screening CLL-like MBL is exceedingly rare and definitely lower than that of clinical MBL and (2) chromosomal abnormalities occur early in the natural history and are possibly associated with the appearance of the typical phenotype.

Original languageEnglish
Pages (from-to)6618-6625
Number of pages8
JournalBlood
Volume118
Issue number25
DOIs
Publication statusPublished - Dec 15 2011

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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    Fazi, C., Scarfò, L., Pecciarini, L., Cottini, F., Dagklis, A., Janus, A., Talarico, A., Scielzo, C., Sala, C., Toniolo, D., Caligaris-Cappio, F., & Ghia, P. (2011). General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood, 118(25), 6618-6625. https://doi.org/10.1182/blood-2011-05-357251