Generalised sensory system abnormalities in amyotrophic lateral sclerosis: A European multicentre study

K. Pugdahl, A. Fuglsang-Frederiksen, M. De Carvalho, B. Johnsen, P. R W Fawcett, A. Labarre-Vila, R. Liguori, W. A. Nix, I. S. Schofield

Research output: Contribution to journalArticle

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Abstract

Background: Amyotrophic lateral sclerosis (ALS) is defined as a disease of the motor neurones, although several studies indicate involvement of the sensory nervous system. Aim: To evaluate the sensory nerve conduction studies (NCS) in 88 patients with ALS as part of a European multicentre study. Methods: Seven European clinical neurophysiologists examined consecutive series of ALS patients. The examinations were peer reviewed, and the diagnosis of ALS was confirmed clinically. Results: 20 (22.7%) patients with ALS had sensory NCS abnormalities in at least one nerve. Of those, 11 (12.5% of all patients) obtained an additional peer review diagnosis of electrophysiological polyneuropathy. There was no difference between the subgroups of patients with normal versus abnormal sensory NCS findings with respect to age, duration and region of onset. Conclusion: The findings support previous reports of sensory involvement in ALS, and raise the question of whether patients with ALS with sensory nerve abnormalities represent a variant of ALS. ALS associated with generalised sensory system abnormalities may be consistent with degeneration of motor neurones and dorsal root ganglion cells.

Original languageEnglish
Pages (from-to)746-749
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
Issue number7
DOIs
Publication statusPublished - Jul 2007

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Amyotrophic Lateral Sclerosis
Multicenter Studies
Neural Conduction
Motor Neuron Disease
Peer Review
Polyneuropathies
Spinal Ganglia
Motor Neurons
Nervous System

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Pugdahl, K., Fuglsang-Frederiksen, A., De Carvalho, M., Johnsen, B., Fawcett, P. R. W., Labarre-Vila, A., ... Schofield, I. S. (2007). Generalised sensory system abnormalities in amyotrophic lateral sclerosis: A European multicentre study. Journal of Neurology, Neurosurgery and Psychiatry, 78(7), 746-749. https://doi.org/10.1136/jnnp.2006.098533

Generalised sensory system abnormalities in amyotrophic lateral sclerosis : A European multicentre study. / Pugdahl, K.; Fuglsang-Frederiksen, A.; De Carvalho, M.; Johnsen, B.; Fawcett, P. R W; Labarre-Vila, A.; Liguori, R.; Nix, W. A.; Schofield, I. S.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 78, No. 7, 07.2007, p. 746-749.

Research output: Contribution to journalArticle

Pugdahl, K, Fuglsang-Frederiksen, A, De Carvalho, M, Johnsen, B, Fawcett, PRW, Labarre-Vila, A, Liguori, R, Nix, WA & Schofield, IS 2007, 'Generalised sensory system abnormalities in amyotrophic lateral sclerosis: A European multicentre study', Journal of Neurology, Neurosurgery and Psychiatry, vol. 78, no. 7, pp. 746-749. https://doi.org/10.1136/jnnp.2006.098533
Pugdahl, K. ; Fuglsang-Frederiksen, A. ; De Carvalho, M. ; Johnsen, B. ; Fawcett, P. R W ; Labarre-Vila, A. ; Liguori, R. ; Nix, W. A. ; Schofield, I. S. / Generalised sensory system abnormalities in amyotrophic lateral sclerosis : A European multicentre study. In: Journal of Neurology, Neurosurgery and Psychiatry. 2007 ; Vol. 78, No. 7. pp. 746-749.
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