Abstract
Generalized gastrointestinal juvenile polyposis is a rare form of diffuse polyposis in which cancer infrequently develops. A clinical case is described in which gastric polyps showed a variety of histological features, including both in situ and invasive adenocarcinoma. Many mixed lesions were observed, confirming a morphological sequence already documented in colorectal tumorigenesis but still undefined in gastric tumors. The patient seems strongly predisposed to gastric cancer, presumably on a genetic basis, because he developed a malignancy in a hyperplastic juvenile polyp, usually not considered a precancerous lesion. There is no doubt that cases like this may be important for accurate genetic evaluation and biological characterization.
Original language | English |
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Pages (from-to) | 910-915 |
Number of pages | 6 |
Journal | Gastroenterology |
Volume | 104 |
Issue number | 3 |
Publication status | Published - 1993 |
ASJC Scopus subject areas
- Gastroenterology