Generalized pustular versus common psoriasis: Differences in the immune response

P. D. Pigatto, F. Riva, A. Radaelli

Research output: Contribution to journalArticlepeer-review

Abstract

In 12 patients with generalized pustular psoriasis (GPP) and in 12 with vulgar psoriasis (VP) the immunological status was checked out including humoral and cellular component of the immune system as well as HLA typing. In contrast to common psoriasis the chemotactic activities of PMN(s) were found to be enhanced in GPP while the superoxide anion generation and IgA values in GPP group were decreased associated with an increase in ceruloplasmin values. Our data also show a higher level of C3, C4, C3PA components of complement. Lymphocyte response to PHA, ConA, PWM as well as intracutaneous tests reactivity were found to be the same in 2 groups. The monoclonal typing of peripheral lymphocytes showed a normal T lymphocyte population (OKT3) and helper/inducer T lymphocytes (OKT4) and a decrease in suppressor/cytotoxic T lymphocytes (OKT8) with an enhancement of the immuno-regulation index (OKT4/OKT8) in the pustular psoriasis group. Our data support the view that these two conditions are immunologically unalike.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalActa Dermato-Venereologica
Volume64
Issue numberSUPPL. 113
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Dermatology

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