Generation and interpretation of context-specific human protein–protein interaction networks with HIPPIE

Gregorio Alanis-Lobato, Martin H. Schaefer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

High-throughput techniques for the detection of protein–protein interactions (PPIs) have enabled a systems approach for the study of the living cell. However, the increasing amount of protein interaction data, the varying quality of these measurements, and the lack of context information make it difficult to construct meaningful and reliable protein networks. The Human Integrated Protein–Protein Interaction rEference (HIPPIE) is a web tool that integrates and annotates experimentally supported human PPIs from a heterogeneous set of data sources. In HIPPIE, one can query for the interactors of one or more proteins and generate high-quality and context-specific networks. This chapter highlights HIPPIE’s most important features and exemplifies its functionality through a proposed use case.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages135-144
Number of pages10
DOIs
Publication statusPublished - Jan 1 2020

Publication series

NameMethods in Molecular Biology
Volume2074
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Context-specific networks
  • Network biology
  • Protein network
  • Protein–protein interactions
  • Systems biology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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