Generation of myocardial factor images directly from the dynamic oxygen- 15-water scan without use of an oxygen-15-carbon monoxide blood-pool scan

Flemming Hermansen, John Ashburner, Terry J. Spinks, Jaspai S. Kooner, Paolo G. Camici, Adriaan A. Lammertsma

Research output: Contribution to journalArticlepeer-review

Abstract

The measurement of regional myocardial blood flow (MBF) with H 2 15O and PET requires an additional C 15O blood-pool scan for the purpose of region of interest (ROI) definition. This additional scan results in a substantially increased radiation dose, study duration and risk of movement artifacts. Therefore, a method was developed to generate myocardial factor images directly from the dynamic H 2 15O study without the need for a C 15O scan. Methods: The factor sinograms were generated by means of linear dimension reduction of the dynamic sinograms, where the required variate and covariate factors (myocardial and blood time-activity curves) were modeled from the lung time-activity curve. The factor images were generated by iterative reconstruction. Results: No significant difference was found between MBF values from ROIs drawn on the traditional images (using the C 15O scan) and those drawn on the factor-images. Conclusion: It is possible to generate myocardial images directly from the dynamic H 2 15O study, so that the C 15O scan can be omitted from MBF studies. The proposed method is robust and results in nearly optimal signal-to-noise ratios in the factor images.

Original languageEnglish
Pages (from-to)1696-1702
Number of pages7
JournalJournal of Nuclear Medicine
Volume39
Issue number10
Publication statusPublished - Oct 1998

Keywords

  • Factor analysis
  • Myocardial and blood-pool images
  • Myocardial blood flow
  • PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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