Generation of non-MHC restricted killing in cultures stimulated with B cells from chronic lymphocytic leukaemia patients: Phenotypic characterization of the precursor and effector cells

L. Matera, R. Foa, F. Malavasi, G. Bellone, A. Funaro, F. Veglia, D. Santoli

Research output: Contribution to journalArticlepeer-review

Abstract

Freshly isolated B cells from chronic lymphocytic leukaemia patients (B-CLL) have been previously shown to induce a strong proliferative response and high levels of NK-like activity in lymphocytes from healthy donors. The present paper deals with the origin, mitotic state, target spectrum and cell surface phenotype of the NK-like effectors generated after stimulation with B-CLL. Experiments using large granular lymphocytes (LGL) and T cells as responders demonstrated that most of the precursors of the newly generated NK-like effectors express the CD3 antigen. The induction of NK-like activity paralleled cell activation, as judged by blast transformation, thymidine uptake and appearance of cell surface activation markers. The newly generated NK-like effectors displayed a T cell phenotype and a broader target repertoire than native NK cells.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalClinical and Experimental Immunology
Volume72
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

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