Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura; Yee-Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J Schwartz; Hung-Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura, Yee-Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi

Research output: Contribution to journal › Article › peer-review

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Pages (from-to)	101431
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101431
Publication status	Published - May 2019

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Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. / Mura, Manuela; Lee, Yee-Ki; Pisano, Federica; Ginevrino, Monia ; Boni, Marina ; Calabrò, Federica ; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J; Tse, Hung-Fat; Gnecchi, Massimiliano.

In: Stem Cell Research, Vol. 37, 05.2019, p. 101431.

Research output: Contribution to journal › Article › peer-review

Mura, Manuela ; Lee, Yee-Ki ; Pisano, Federica ; Ginevrino, Monia ; Boni, Marina ; Calabrò, Federica ; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J ; Tse, Hung-Fat ; Gnecchi, Massimiliano. / Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. In: Stem Cell Research. 2019 ; Vol. 37. pp. 101431.

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abstract = "We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).",

author = "Manuela Mura and Yee-Ki Lee and Federica Pisano and Monia Ginevrino and Marina Boni and Federica Calabr{\`o} and Lia Crotti and Valente, {Enza Maria} and Schwartz, {Peter J} and Hung-Fat Tse and Massimiliano Gnecchi",

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AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

AU - Valente, Enza Maria

AU - Schwartz, Peter J

AU - Tse, Hung-Fat

AU - Gnecchi, Massimiliano

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AB - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

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