Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura; Yee-Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J Schwartz; Hung-Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura, Yee-Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi

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Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Pages (from-to)	101431
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101431
Publication status	Published - May 2019

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10.1016/j.scr.2019.101431

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title = "Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation",

abstract = "We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).",

author = "Manuela Mura and Yee-Ki Lee and Federica Pisano and Monia Ginevrino and Marina Boni and Federica Calabr{\`o} and Lia Crotti and Valente, {Enza Maria} and Schwartz, {Peter J} and Hung-Fat Tse and Massimiliano Gnecchi",

year = "2019",

month = may,

doi = "10.1016/j.scr.2019.101431",

language = "English",

volume = "37",

pages = "101431",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

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TY - JOUR

T1 - Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

AU - Mura, Manuela

AU - Lee, Yee-Ki

AU - Pisano, Federica

AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

AU - Valente, Enza Maria

AU - Schwartz, Peter J

AU - Tse, Hung-Fat

AU - Gnecchi, Massimiliano

PY - 2019/5

Y1 - 2019/5

N2 - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

AB - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

U2 - 10.1016/j.scr.2019.101431

DO - 10.1016/j.scr.2019.101431

M3 - Article

C2 - 30974404

VL - 37

SP - 101431

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

ER -

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Abstract

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