Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Manuela Mura; Yee-Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J Schwartz; Hung-Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101437

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Manuela Mura, Yee-Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi

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Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Pages (from-to)	101437
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101437
Publication status	Published - May 2019

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title = "Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation",

abstract = "We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).",

author = "Manuela Mura and Yee-Ki Lee and Federica Pisano and Monia Ginevrino and Marina Boni and Federica Calabr{\`o} and Lia Crotti and Valente, {Enza Maria} and Schwartz, {Peter J} and Hung-Fat Tse and Massimiliano Gnecchi",

year = "2019",

month = may,

doi = "10.1016/j.scr.2019.101437",

language = "English",

volume = "37",

pages = "101437",

journal = "Stem Cell Research",

issn = "1873-5061",

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TY - JOUR

T1 - Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

AU - Mura, Manuela

AU - Lee, Yee-Ki

AU - Pisano, Federica

AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

AU - Valente, Enza Maria

AU - Schwartz, Peter J

AU - Tse, Hung-Fat

AU - Gnecchi, Massimiliano

PY - 2019/5

Y1 - 2019/5

N2 - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

AB - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

U2 - 10.1016/j.scr.2019.101437

DO - 10.1016/j.scr.2019.101437

M3 - Article

C2 - 31009818

VL - 37

SP - 101437

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

ER -

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Abstract

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