Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Manuela Mura; Yee-Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J Schwartz; Hung-Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101437

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Manuela Mura, Yee-Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi

Research output: Contribution to journal › Article

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Pages (from-to)	101437
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101437
Publication status	Published - May 2019

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Mura, M., Lee, Y-K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H-F., & Gnecchi, M. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. Stem Cell Research, 37, 101437. https://doi.org/10.1016/j.scr.2019.101437

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. / Mura, Manuela; Lee, Yee-Ki; Pisano, Federica; Ginevrino, Monia; Boni, Marina; Calabrò, Federica; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J; Tse, Hung-Fat; Gnecchi, Massimiliano.

In: Stem Cell Research, Vol. 37, 05.2019, p. 101437.

Research output: Contribution to journal › Article

Mura, Manuela ; Lee, Yee-Ki ; Pisano, Federica ; Ginevrino, Monia ; Boni, Marina ; Calabrò, Federica ; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J ; Tse, Hung-Fat ; Gnecchi, Massimiliano. / Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. In: Stem Cell Research. 2019 ; Vol. 37. pp. 101437.

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AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

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AU - Tse, Hung-Fat

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