Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura; Yee Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J. Schwartz; Hung Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura, Yee Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J. Schwartz, Hung Fat Tse, Massimiliano Gnecchi

Research output: Contribution to journal › Article

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Article number	101431
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101431
Publication status	Published - May 1 2019

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Induced Pluripotent Stem Cells

Cell Line

Mutation

Pluripotent Stem Cells

Retroviridae

Cardiac Myocytes

Fibroblasts

Skin

Genes

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Cite this

Mura, M., Lee, Y. K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., ... Gnecchi, M. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Stem Cell Research, 37, [101431]. https://doi.org/10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. / Mura, Manuela; Lee, Yee Ki; Pisano, Federica; Ginevrino, Monia; Boni, Marina ; Calabrò, Federica ; Crotti, Lia; Valente, Enza Maria; Schwartz, Peter J.; Tse, Hung Fat; Gnecchi, Massimiliano.

In: Stem Cell Research, Vol. 37, 101431, 01.05.2019.

Research output: Contribution to journal › Article

Mura, M, Lee, YK, Pisano, F, Ginevrino, M, Boni, M , Calabrò, F , Crotti, L, Valente, EM, Schwartz, PJ, Tse, HF & Gnecchi, M 2019, 'Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation', Stem Cell Research, vol. 37, 101431. https://doi.org/10.1016/j.scr.2019.101431

Mura M, Lee YK, Pisano F, Ginevrino M, Boni M , Calabrò F et al. Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Stem Cell Research. 2019 May 1;37. 101431. https://doi.org/10.1016/j.scr.2019.101431

Mura, Manuela ; Lee, Yee Ki ; Pisano, Federica ; Ginevrino, Monia ; Boni, Marina ; Calabrò, Federica ; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J. ; Tse, Hung Fat ; Gnecchi, Massimiliano. / Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. In: Stem Cell Research. 2019 ; Vol. 37.

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10.1016/j.scr.2019.101431