Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

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Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original languageEnglish
Article number101431
JournalStem Cell Research
Volume37
DOIs
Publication statusPublished - May 1 2019

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Induced Pluripotent Stem Cells
Cell Line
Mutation
Pluripotent Stem Cells
Retroviridae
Cardiac Myocytes
Fibroblasts
Skin
Genes

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

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title = "Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation",
abstract = "We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).",
author = "Manuela Mura and Lee, {Yee Ki} and Federica Pisano and Monia Ginevrino and Marina Boni and Federica Calabr{\`o} and Lia Crotti and Valente, {Enza Maria} and Schwartz, {Peter J.} and Tse, {Hung Fat} and Massimiliano Gnecchi",
year = "2019",
month = "5",
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doi = "10.1016/j.scr.2019.101431",
language = "English",
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journal = "Stem Cell Research",
issn = "1873-5061",
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T1 - Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

AU - Mura, Manuela

AU - Lee, Yee Ki

AU - Pisano, Federica

AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

AU - Valente, Enza Maria

AU - Schwartz, Peter J.

AU - Tse, Hung Fat

AU - Gnecchi, Massimiliano

PY - 2019/5/1

Y1 - 2019/5/1

N2 - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

AB - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

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SN - 1873-5061

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