Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura; Yee Ki Lee; Federica Pisano; Monia Ginevrino; Marina Boni; Federica Calabrò; Lia Crotti; Enza Maria Valente; Peter J. Schwartz; Hung Fat Tse; Massimiliano Gnecchi

doi:10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Manuela Mura, Yee Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J. Schwartz, Hung Fat Tse, Massimiliano Gnecchi

Research output: Contribution to journal › Article

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original language	English
Article number	101431
Journal	Stem Cell Research
Volume	37
DOIs	https://doi.org/10.1016/j.scr.2019.101431
Publication status	Published - May 1 2019

Fingerprint

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Cite this

Mura, M., Lee, Y. K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H. F., & Gnecchi, M. (2019). Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Stem Cell Research, 37, [101431]. https://doi.org/10.1016/j.scr.2019.101431

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. / Mura, Manuela; Lee, Yee Ki; Pisano, Federica; Ginevrino, Monia; Boni, Marina; Calabrò, Federica; Crotti, Lia ; Valente, Enza Maria ; Schwartz, Peter J.; Tse, Hung Fat; Gnecchi, Massimiliano.

In: Stem Cell Research, Vol. 37, 101431, 01.05.2019.

Research output: Contribution to journal › Article

@article{fafb36c92bef490b98e1166e91ad8659,

title = "Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation",

abstract = "We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).",

author = "Manuela Mura and Lee, {Yee Ki} and Federica Pisano and Monia Ginevrino and Marina Boni and Federica Calabr{\`o} and Lia Crotti and Valente, {Enza Maria} and Schwartz, {Peter J.} and Tse, {Hung Fat} and Massimiliano Gnecchi",

year = "2019",

month = may

day = "1",

doi = "10.1016/j.scr.2019.101431",

language = "English",

volume = "37",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

AU - Mura, Manuela

AU - Lee, Yee Ki

AU - Pisano, Federica

AU - Ginevrino, Monia

AU - Boni, Marina

AU - Calabrò, Federica

AU - Crotti, Lia

AU - Valente, Enza Maria

AU - Schwartz, Peter J.

AU - Tse, Hung Fat

AU - Gnecchi, Massimiliano

PY - 2019/5/1

Y1 - 2019/5/1

N2 - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

AB - We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

UR - http://www.scopus.com/inward/record.url?scp=85063950564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063950564&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2019.101431

DO - 10.1016/j.scr.2019.101431

M3 - Article

AN - SCOPUS:85063950564

VL - 37

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 101431

ER -

Access to Document

10.1016/j.scr.2019.101431

Projects

SAN MATTEO - MEDICINA RIGENERATIVA; DIAGNOSTICA E TERAPIA CELLULARE

Project: Other project

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Abstract

Fingerprint

ASJC Scopus subject areas

Cite this

Access to Document

Related content

Projects

SAN MATTEO - MEDICINA RIGENERATIVA; DIAGNOSTICA E TERAPIA CELLULARE