Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Manuela Mura, Yee Ki Lee, Federica Pisano, Monia Ginevrino, Marina Boni, Federica Calabrò, Lia Crotti, Enza Maria Valente, Peter J. Schwartz, Hung Fat Tse, Massimiliano Gnecchi

Research output: Contribution to journalArticlepeer-review

Abstract

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

Original languageEnglish
Article number101437
JournalStem Cell Research
Volume37
DOIs
Publication statusPublished - May 1 2019

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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