Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Calabrò Marco, Drago Antonio, Sidoti Antonina, Serretti Alessandro, Crisafulli Concetta

Research output: Contribution to journalArticle

Abstract

A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalPsychiatry Research
Volume228
Issue number3
DOIs
Publication statusPublished - Aug 30 2015

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Keywords

  • Pathway analysis
  • Pruning
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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