TY - JOUR
T1 - Genetic abnormalities of the protein C system
T2 - Shared risk factors in young adults with migraine with aura and with ischemic stroke?
AU - D'Amico, D.
AU - Moschiano, F.
AU - Leone, M.
AU - Ariano, C.
AU - Ciusani, E.
AU - Erba, N.
AU - Grazzi, L.
AU - Ferraris, A.
AU - Schieroni, F.
AU - Bussone, G.
PY - 1998
Y1 - 1998
N2 - Migraine, particularly migraine with aura (MA), may be a risk factor for ischemic stroke (IS). The reasons for this association are unknown. We investigated the presence of genetic abnormalities of the protein C system in 83 MA patients, 31 IS patients, and 124 healthy controls, all aged under 45 years. We found an increased frequency of activated protein C resistance due to Arg506Gln factor V mutation, and of protein S deficiency in both disorders, with figures higher than those reported in the general population and significantly different from those found in controls. These prothrombotic genetic abnormalities may be shared risk factors in IS and MA, and may play a role in increasing the risk of cerebrovascular disease in migraineurs.
AB - Migraine, particularly migraine with aura (MA), may be a risk factor for ischemic stroke (IS). The reasons for this association are unknown. We investigated the presence of genetic abnormalities of the protein C system in 83 MA patients, 31 IS patients, and 124 healthy controls, all aged under 45 years. We found an increased frequency of activated protein C resistance due to Arg506Gln factor V mutation, and of protein S deficiency in both disorders, with figures higher than those reported in the general population and significantly different from those found in controls. These prothrombotic genetic abnormalities may be shared risk factors in IS and MA, and may play a role in increasing the risk of cerebrovascular disease in migraineurs.
KW - Activated protein C (APC) resistance
KW - Ischemic stroke
KW - Migraine with aura
KW - Protein C system
KW - Protein S deficiency
KW - Risk factors
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U2 - 10.1046/j.1468-2982.1998.1809618.x
DO - 10.1046/j.1468-2982.1998.1809618.x
M3 - Article
C2 - 9876885
AN - SCOPUS:0032429823
VL - 18
SP - 618
EP - 621
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 9
ER -