Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients

Faina Vikhanskaya, Massimo Broggini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The cellular response to anticancer agent treatments is determined by many factors that could be altered in tumor cells. The induction of apoptosis of cancer cells is thought to be important for the overall response of these cells. Despite the introduction of new and potent anticancer agents, the survival rate for patients with ovarian cancer remains poor. In general ovarian cancer cells present a poor propensity to undergo apoptosis, which could be one of the reasons for this relatively poor response observed in the clinic. Induction of apoptosis is the result of activation and repression of pro- and antiapoptotic genes, which are regulated by complex mechanisms. Many cancer cells activate a "survival" program to escape disruption and allow propagation. In this review we have analyzed the role of genetic alterations observed in ovarian cancer cells in determining cellular response to drug treatment.

Original languageEnglish
Pages (from-to)157-198
Number of pages42
JournalInternational Review of Cytology
Volume219
DOIs
Publication statusPublished - 2002

Fingerprint

Ovarian Neoplasms
Drug Therapy
Apoptosis
Antineoplastic Agents
Neoplasms
Survival Rate
Survival
Therapeutics
Pharmaceutical Preparations
Genes

Keywords

  • Anticancer agents
  • Apoptosis
  • Gene mutations
  • Ovarian cancer

ASJC Scopus subject areas

  • Cell Biology
  • Histology

Cite this

Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients. / Vikhanskaya, Faina; Broggini, Massimo.

In: International Review of Cytology, Vol. 219, 2002, p. 157-198.

Research output: Contribution to journalArticle

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