Abstract
The cellular response to anticancer agent treatments is determined by many factors that could be altered in tumor cells. The induction of apoptosis of cancer cells is thought to be important for the overall response of these cells. Despite the introduction of new and potent anticancer agents, the survival rate for patients with ovarian cancer remains poor. In general ovarian cancer cells present a poor propensity to undergo apoptosis, which could be one of the reasons for this relatively poor response observed in the clinic. Induction of apoptosis is the result of activation and repression of pro- and antiapoptotic genes, which are regulated by complex mechanisms. Many cancer cells activate a "survival" program to escape disruption and allow propagation. In this review we have analyzed the role of genetic alterations observed in ovarian cancer cells in determining cellular response to drug treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 157-198 |
| Number of pages | 42 |
| Journal | International Review of Cytology |
| Volume | 219 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Anticancer agents
- Apoptosis
- Gene mutations
- Ovarian cancer
ASJC Scopus subject areas
- Cell Biology
- Histology
Cite this
Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients. / Vikhanskaya, Faina; Broggini, Massimo.
In: International Review of Cytology, Vol. 219, 2002, p. 157-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients
AU - Vikhanskaya, Faina
AU - Broggini, Massimo
PY - 2002
Y1 - 2002
N2 - The cellular response to anticancer agent treatments is determined by many factors that could be altered in tumor cells. The induction of apoptosis of cancer cells is thought to be important for the overall response of these cells. Despite the introduction of new and potent anticancer agents, the survival rate for patients with ovarian cancer remains poor. In general ovarian cancer cells present a poor propensity to undergo apoptosis, which could be one of the reasons for this relatively poor response observed in the clinic. Induction of apoptosis is the result of activation and repression of pro- and antiapoptotic genes, which are regulated by complex mechanisms. Many cancer cells activate a "survival" program to escape disruption and allow propagation. In this review we have analyzed the role of genetic alterations observed in ovarian cancer cells in determining cellular response to drug treatment.
AB - The cellular response to anticancer agent treatments is determined by many factors that could be altered in tumor cells. The induction of apoptosis of cancer cells is thought to be important for the overall response of these cells. Despite the introduction of new and potent anticancer agents, the survival rate for patients with ovarian cancer remains poor. In general ovarian cancer cells present a poor propensity to undergo apoptosis, which could be one of the reasons for this relatively poor response observed in the clinic. Induction of apoptosis is the result of activation and repression of pro- and antiapoptotic genes, which are regulated by complex mechanisms. Many cancer cells activate a "survival" program to escape disruption and allow propagation. In this review we have analyzed the role of genetic alterations observed in ovarian cancer cells in determining cellular response to drug treatment.
KW - Anticancer agents
KW - Apoptosis
KW - Gene mutations
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=0035995285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035995285&partnerID=8YFLogxK
U2 - 10.1016/S0074-7696(02)19013-9
DO - 10.1016/S0074-7696(02)19013-9
M3 - Article
VL - 219
SP - 157
EP - 198
JO - International Review of Cytology
JF - International Review of Cytology
SN - 0074-7696
ER -