Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease

Silke Metzger, Peter Bauer, Jürgen Tomiuk, Franco Laccone, Stefano DiDonato, Cinzia Gellera, Caterina Mariotti, Herwig W. Lange, Halger Weirich-Schwaiger, Gregor K. Wenning, Klaus Seppi, Bela Melegh, Viktoria Havasi, Laszlo Balikó, Stefan Wieczorek, Jacek Zaremba, Dorota Hoffman-Zacharska, Anna Sulek, A. Nazli Basak, Esra SoydanJana Zidovska, Vera Kebrdlova, Massimo Pandolfo, Pascale Ribaï, Ludovit Kadasi, Marta Kvasnicova, Bernhard H F Weber, Friedmar Kreuz, Matthias Dose, Manfred Stuhrmann, Olaf Riess

Research output: Contribution to journalArticlepeer-review

Abstract

The expansion of a polymorphic CAG repeat in the HD gene encoding huntingtin has been identified as the major cause of Huntington's disease (HD) and determines 42-73% of the variance in the age-at-onset of the disease. Polymorphisms in huntingtin interacting or associated genes are thought to modify the course of the disease. To identify genetic modifiers influencing the age at disease onset, we searched for polymorphic markers in the GRIK2, TBP, BDNF, HIP1 and ZDHHC17 genes and analysed seven of them by association studies in 980 independent European HD patients. Screening for unknown sequence variations we found besides several silent variations three polymorphisms in the ZDHHC17 gene. These and polymorphisms in the GRIK2, TBP and BDNF genes were analysed with respect to their association with the HD age-at-onset. Although some of the factors have been defined as genetic modifier factors in previous studies, none of the genes encoding GRIK2, TBP, BDNF and ZDHHC17 could be identified as a genetic modifier for HD.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalHuman Genetics
Volume120
Issue number2
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Age-at-onset
  • Association study
  • Genetic modifiers
  • Huntington's disease

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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