Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena, B Mifsud, R Pazoki, H Gao, G Ntritsos, N Dimou, CP Cabrera, I Karaman, FL Ng, M Evangelou, K Witkowska, E Tzanis, JN Hellwege, A Giri, DR Velez Edwards, YV Sun, K Cho, JM GazianoPWF Wilson, PS Tsao, CP Kovesdy, T Esko, R Mägi, L Milani, P Almgren, T Boutin, S Debette, J Ding, F Giulianini, EG Holliday, AU Jackson, R Li-Gao, WY Lin, J Luan, M Mangino, C Oldmeadow, BP Prins, Y Qian, M Sargurupremraj, N Shah, P Surendran, S Thériault, N Verweij, SM Willems, JH Zhao, P Amouyel, J Connell, R de Mutsert, ASF Doney, M Farrall, C Menni, AD Morris, R Noordam, G Paré, NR Poulter, DC Shields, A Stanton, S Thom, G Abecasis, N Amin, DE Arking, KL Ayers, CM Barbieri, C Batini, JC Bis, T Blake, M Bochud, M Boehnke, E Boerwinkle, DI Boomsma, EP Bottinger, PS Braund, M Brumat, A Campbell, H Campbell, A Chakravarti, JC Chambers, G Chauhan, M Ciullo, M Cocca, F Collins, HJ Cordell, G Davies, MH Borst, EJ Geus, IJ Deary, J Deelen, F Del Greco M, CY Demirkale, M Dörr, GB Ehret, R Elosua, S Enroth, AM Erzurumluoglu, T Ferreira, M Frånberg, OH Franco, I Gandin, P Gasparini, V Giedraitis, C Gieger, G Girotto, A Goel, AJ Gow, V Gudnason, X Guo, U Gyllensten, A Hamsten, TB Harris, SE Harris, CA Hartman, AS Havulinna, AA Hicks, E Hofer, A Hofman, JJ Hottenga, JE Huffman, SJ Hwang, E Ingelsson, A James, R Jansen, MR Jarvelin, R Joehanes, Å Johansson, AD Johnson, PK Joshi, P Jousilahti, JW Jukema, A Jula, M Kähönen, S Kathiresan, BD Keavney, KT Khaw, P Knekt, J Knight, I Kolcic, JS Kooner, S Koskinen, K Kristiansson, Z Kutalik, M Laan, M Larson, LJ Launer, B Lehne, T Lehtimäki, DCM Liewald, L Lin, L Lind, CM Lindgren, Y Liu, RJF Loos, LM Lopez, Y Lu, LP Lyytikäinen, A Mahajan, C Mamasoula, J Marrugat, J Marten, Y Milaneschi, A Morgan, AP Morris, AC Morrison, PJ Munson, MA Nalls, P Nandakumar, CP Nelson, T Niiranen, IM Nolte, T Nutile, AJ Oldehinkel, BA Oostra, PF O'Reilly, E Org, S Padmanabhan, W Palmas, A Palotie, A Pattie, BWJH Penninx, M Perola, A Peters, O Polasek, PP Pramstaller, QT Nguyen, OT Raitakari, M Ren, R Rettig, K Rice, PM Ridker, JS Ried, H Riese, S Ripatti, A Robino, LM Rose, JI Rotter, I Rudan, D Ruggiero, Y Saba, CF Sala, V Salomaa, NJ Samani, AP Sarin, R Schmidt, H Schmidt, N Shrine, D Siscovick, AV Smith, H Snieder, S Sõber, R Sorice, JM Starr, DJ Stott, DP Strachan, RJ Strawbridge, J Sundström, MA Swertz, KD Taylor, A Teumer, MD Tobin, M Tomaszewski, D Toniolo, M Traglia, S Trompet, J Tuomilehto, C Tzourio, AG Uitterlinden, A Vaez, PJ van der Most, CM van Duijn, AC Vergnaud, GC Verwoert, V Vitart, U Völker, P Vollenweider, D Vuckovic, H Watkins, SH Wild, G Willemsen, JF Wilson, AF Wright, J Yao, T Zemunik, W Zhang, JR Attia, AS Butterworth, DI Chasman, D Conen, F Cucca, J Danesh, C Hayward, JMM Howson, M Laakso, EG Lakatta, C Langenberg, O Melander, DO Mook-Kanamori, CNA Palmer, L Risch, RA Scott, RJ Scott, P Sever, TD Spector, P van der Harst, NJ Wareham, E Zeggini, D Levy, PB Munroe, C Newton-Cheh, MJ Brown, A Metspalu, AM Hung, CJ O'Donnell, TL Edwards, Million Veteran Program, BM Psaty, I Tzoulaki, MR Barnes, LV Wain, P Elliott, MJ Caulfield

Research output: Contribution to journalArticle

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
Original languageEnglish
Pages (from-to)1412-1425
Number of pages14
JournalNature Genetics
Volume50
Issue number10
DOIs
Publication statusPublished - 2018

    Fingerprint

Cite this

Evangelou, E., Warren, HR., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, CP., Karaman, I., Ng, FL., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, JN., Giri, A., Velez Edwards, DR., Sun, YV., Cho, K., ... Caulfield, MJ. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-1425. https://doi.org/10.1038/s41588-018-0205-x