Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou; HR Warren; D Mosen-Ansorena; B Mifsud; R Pazoki; H Gao; G Ntritsos; N Dimou; CP Cabrera; I Karaman; FL Ng; M Evangelou; K Witkowska; E Tzanis; JN Hellwege; A Giri; DR Velez Edwards; YV Sun; K Cho; JM Gaziano; PWF Wilson; PS Tsao; CP Kovesdy; T Esko; R Mägi; L Milani; P Almgren; T Boutin; S Debette; J Ding; F Giulianini; EG Holliday; AU Jackson; R Li-Gao; WY Lin; J Luan; M Mangino; C Oldmeadow; BP Prins; Y Qian; M Sargurupremraj; N Shah; P Surendran; S Thériault; N Verweij; SM Willems; JH Zhao; P Amouyel; J Connell; R de Mutsert; ASF Doney; M Farrall; C Menni; AD Morris; R Noordam; G Paré; NR Poulter; DC Shields; A Stanton; S Thom; G Abecasis; N Amin; DE Arking; KL Ayers; CM Barbieri; C Batini; JC Bis; T Blake; M Bochud; M Boehnke; E Boerwinkle; DI Boomsma; EP Bottinger; PS Braund; M Brumat; A Campbell; H Campbell; A Chakravarti; JC Chambers; G Chauhan; M Ciullo; M Cocca; F Collins; HJ Cordell; G Davies; MH Borst; EJ Geus; IJ Deary; J Deelen; F Del Greco M; CY Demirkale; M Dörr; GB Ehret; R Elosua; S Enroth; AM Erzurumluoglu; T Ferreira; M Frånberg; OH Franco; I Gandin; P Gasparini; V Giedraitis; C Gieger; G Girotto; A Goel; AJ Gow; V Gudnason; X Guo; U Gyllensten; A Hamsten; TB Harris; SE Harris; CA Hartman; AS Havulinna; AA Hicks; E Hofer; A Hofman; JJ Hottenga; JE Huffman; SJ Hwang; E Ingelsson; A James; R Jansen; MR Jarvelin; R Joehanes; Å Johansson; AD Johnson; PK Joshi; P Jousilahti; JW Jukema; A Jula; M Kähönen; S Kathiresan; BD Keavney; KT Khaw; P Knekt; J Knight; I Kolcic; JS Kooner; S Koskinen; K Kristiansson; Z Kutalik; M Laan; M Larson; LJ Launer; B Lehne; T Lehtimäki; DCM Liewald; L Lin; L Lind; CM Lindgren; Y Liu; RJF Loos; LM Lopez; Y Lu; LP Lyytikäinen; A Mahajan; C Mamasoula; J Marrugat; J Marten; Y Milaneschi; A Morgan; AP Morris; AC Morrison; PJ Munson; MA Nalls; P Nandakumar; CP Nelson; T Niiranen; IM Nolte; T Nutile; AJ Oldehinkel; BA Oostra; PF O'Reilly; E Org; S Padmanabhan; W Palmas; A Palotie; A Pattie; BWJH Penninx; M Perola; A Peters; O Polasek; PP Pramstaller; QT Nguyen; OT Raitakari; M Ren; R Rettig; K Rice; PM Ridker; JS Ried; H Riese; S Ripatti; A Robino; LM Rose; JI Rotter; I Rudan; D Ruggiero; Y Saba; CF Sala; V Salomaa; NJ Samani; AP Sarin; R Schmidt; H Schmidt; N Shrine; D Siscovick; AV Smith; H Snieder; S Sõber; R Sorice; JM Starr; DJ Stott; DP Strachan; RJ Strawbridge; J Sundström; MA Swertz; KD Taylor; A Teumer; MD Tobin; M Tomaszewski; D Toniolo; M Traglia; S Trompet; J Tuomilehto; C Tzourio; AG Uitterlinden; A Vaez; PJ van der Most; CM van Duijn; AC Vergnaud; GC Verwoert; V Vitart; U Völker; P Vollenweider; D Vuckovic; H Watkins; SH Wild; G Willemsen; JF Wilson; AF Wright; J Yao; T Zemunik; W Zhang; JR Attia; AS Butterworth; DI Chasman; D Conen; F Cucca; J Danesh; C Hayward; JMM Howson; M Laakso; EG Lakatta; C Langenberg; O Melander; DO Mook-Kanamori; CNA Palmer; L Risch; RA Scott; RJ Scott; P Sever; TD Spector; P van der Harst; NJ Wareham; E Zeggini; D Levy; PB Munroe; C Newton-Cheh; MJ Brown; A Metspalu; AM Hung; CJ O'Donnell; TL Edwards; Million Veteran Program; BM Psaty; I Tzoulaki; MR Barnes; LV Wain; P Elliott; MJ Caulfield

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena, B Mifsud, R Pazoki, H Gao, G Ntritsos, N Dimou, CP Cabrera, I Karaman, FL Ng, M Evangelou, K Witkowska, E Tzanis, JN Hellwege, A Giri, DR Velez Edwards, YV Sun, K Cho, JM GazianoPWF Wilson, PS Tsao, CP Kovesdy, T Esko, R Mägi, L Milani, P Almgren, T Boutin, S Debette, J Ding, F Giulianini, EG Holliday, AU Jackson, R Li-Gao, WY Lin, J Luan, M Mangino, C Oldmeadow, BP Prins, Y Qian, M Sargurupremraj, N Shah, P Surendran, S Thériault, N Verweij, SM Willems, JH Zhao, P Amouyel, J Connell, R de Mutsert, ASF Doney, M Farrall, C Menni, AD Morris, R Noordam, G Paré, NR Poulter, DC Shields, A Stanton, S Thom, G Abecasis, N Amin, DE Arking, KL Ayers, CM Barbieri, C Batini, JC Bis, T Blake, M Bochud, M Boehnke, E Boerwinkle, DI Boomsma, EP Bottinger, PS Braund, M Brumat, A Campbell, H Campbell, A Chakravarti, JC Chambers, G Chauhan, M Ciullo, M Cocca, F Collins, HJ Cordell, G Davies, MH Borst, EJ Geus, IJ Deary, J Deelen, F Del Greco M, CY Demirkale, M Dörr, GB Ehret, R Elosua, S Enroth, AM Erzurumluoglu, T Ferreira, M Frånberg, OH Franco, I Gandin, P Gasparini, V Giedraitis, C Gieger, G Girotto, A Goel, AJ Gow, V Gudnason, X Guo, U Gyllensten, A Hamsten, TB Harris, SE Harris, CA Hartman, AS Havulinna, AA Hicks, E Hofer, A Hofman, JJ Hottenga, JE Huffman, SJ Hwang, E Ingelsson, A James, R Jansen, MR Jarvelin, R Joehanes, Å Johansson, AD Johnson, PK Joshi, P Jousilahti, JW Jukema, A Jula, M Kähönen, S Kathiresan, BD Keavney, KT Khaw, P Knekt, J Knight, I Kolcic, JS Kooner, S Koskinen, K Kristiansson, Z Kutalik, M Laan, M Larson, LJ Launer, B Lehne, T Lehtimäki, DCM Liewald, L Lin, L Lind, CM Lindgren, Y Liu, RJF Loos, LM Lopez, Y Lu, LP Lyytikäinen, A Mahajan, C Mamasoula, J Marrugat, J Marten, Y Milaneschi, A Morgan, AP Morris, AC Morrison, PJ Munson, MA Nalls, P Nandakumar, CP Nelson, T Niiranen, IM Nolte, T Nutile, AJ Oldehinkel, BA Oostra, PF O'Reilly, E Org, S Padmanabhan, W Palmas, A Palotie, A Pattie, BWJH Penninx, M Perola, A Peters, O Polasek, PP Pramstaller, QT Nguyen, OT Raitakari, M Ren, R Rettig, K Rice, PM Ridker, JS Ried, H Riese, S Ripatti, A Robino, LM Rose, JI Rotter, I Rudan, D Ruggiero, Y Saba, CF Sala, V Salomaa, NJ Samani, AP Sarin, R Schmidt, H Schmidt, N Shrine, D Siscovick, AV Smith, H Snieder, S Sõber, R Sorice, JM Starr, DJ Stott, DP Strachan, RJ Strawbridge, J Sundström, MA Swertz, KD Taylor, A Teumer, MD Tobin, M Tomaszewski, D Toniolo, M Traglia, S Trompet, J Tuomilehto, C Tzourio, AG Uitterlinden, A Vaez, PJ van der Most, CM van Duijn, AC Vergnaud, GC Verwoert, V Vitart, U Völker, P Vollenweider, D Vuckovic, H Watkins, SH Wild, G Willemsen, JF Wilson, AF Wright, J Yao, T Zemunik, W Zhang, JR Attia, AS Butterworth, DI Chasman, D Conen, F Cucca, J Danesh, C Hayward, JMM Howson, M Laakso, EG Lakatta, C Langenberg, O Melander, DO Mook-Kanamori, CNA Palmer, L Risch, RA Scott, RJ Scott, P Sever, TD Spector, P van der Harst, NJ Wareham, E Zeggini, D Levy, PB Munroe, C Newton-Cheh, MJ Brown, A Metspalu, AM Hung, CJ O'Donnell, TL Edwards, Million Veteran Program, BM Psaty, I Tzoulaki, MR Barnes, LV Wain, P Elliott, MJ Caulfield

Research output: Contribution to journal › Article › peer-review

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

Original language	English
Pages (from-to)	1412-1425
Number of pages	14
Journal	Nature Genetics
Volume	50
Issue number	10
DOIs	https://doi.org/10.1038/s41588-018-0205-x
Publication status	Published - 2018

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10.1038/s41588-018-0205-x

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Cite this

Evangelou, E., Warren, HR., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, CP., Karaman, I., Ng, FL., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, JN., Giri, A., Velez Edwards, DR., Sun, YV., Cho, K., ... Caulfield, MJ. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-1425. https://doi.org/10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrera, CP; Karaman, I; Ng, FL; Evangelou, M; Witkowska, K; Tzanis, E; Hellwege, JN; Giri, A; Velez Edwards, DR; Sun, YV; Cho, K; Gaziano, JM; Wilson, PWF; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Giulianini, F; Holliday, EG; Jackson, AU; Li-Gao, R; Lin, WY; Luan, J; Mangino, M; Oldmeadow, C; Prins, BP; Qian, Y; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, JH; Amouyel, P; Connell, J; de Mutsert, R; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Chauhan, G; Ciullo, M; Cocca, M; Collins, F; Cordell, HJ; Davies, G; Borst, MH; Geus, EJ; Deary, IJ; Deelen, J; Del Greco M, F; Demirkale, CY; Dörr, M; Ehret, GB; Elosua, R; Enroth, S; Erzurumluoglu, AM; Ferreira, T; Frånberg, M; Franco, OH; Gandin, I; Gasparini, P; Giedraitis, V; Gieger, C; Girotto, G; Goel, A; Gow, AJ; Gudnason, V; Guo, X; Gyllensten, U; Hamsten, A; Harris, TB; Harris, SE; Hartman, CA; Havulinna, AS; Hicks, AA; Hofer, E; Hofman, A; Hottenga, JJ; Huffman, JE; Hwang, SJ; Ingelsson, E; James, A; Jansen, R; Jarvelin, MR; Joehanes, R; Johansson, Å; Johnson, AD; Joshi, PK; Jousilahti, P; Jukema, JW; Jula, A; Kähönen, M; Kathiresan, S; Keavney, BD; Khaw, KT; Knekt, P; Knight, J; Kolcic, I; Kooner, JS; Koskinen, S; Kristiansson, K; Kutalik, Z; Laan, M; Larson, M; Launer, LJ; Lehne, B; Lehtimäki, T; Liewald, DCM; Lin, L; Lind, L; Lindgren, CM; Liu, Y; Loos, RJF; Lopez, LM; Lu, Y; Lyytikäinen, LP; Mahajan, A; Mamasoula, C; Marrugat, J; Marten, J; Milaneschi, Y; Morgan, A; Morris, AP; Morrison, AC; Munson, PJ; Nalls, MA; Nandakumar, P; Nelson, CP; Niiranen, T; Nolte, IM; Nutile, T; Oldehinkel, AJ; Oostra, BA; O'Reilly, PF; Org, E; Padmanabhan, S; Palmas, W; Palotie, A; Pattie, A; Penninx, BWJH; Perola, M; Peters, A; Polasek, O; Pramstaller, PP; Nguyen, QT; Raitakari, OT; Ren, M; Rettig, R; Rice, K; Ridker, PM; Ried, JS; Riese, H; Ripatti, S; Robino, A; Rose, LM; Rotter, JI; Rudan, I; Ruggiero, D; Saba, Y; Sala, CF; Salomaa, V; Samani, NJ; Sarin, AP; Schmidt, R; Schmidt, H; Shrine, N; Siscovick, D; Smith, AV; Snieder, H; Sõber, S; Sorice, R; Starr, JM; Stott, DJ; Strachan, DP; Strawbridge, RJ; Sundström, J; Swertz, MA; Taylor, KD; Teumer, A; Tobin, MD; Tomaszewski, M; Toniolo, D; Traglia, M; Trompet, S; Tuomilehto, J; Tzourio, C; Uitterlinden, AG; Vaez, A; van der Most, PJ; van Duijn, CM; Vergnaud, AC; Verwoert, GC; Vitart, V; Völker, U; Vollenweider, P; Vuckovic, D; Watkins, H; Wild, SH; Willemsen, G; Wilson, JF; Wright, AF; Yao, J; Zemunik, T; Zhang, W; Attia, JR; Butterworth, AS; Chasman, DI; Conen, D; Cucca, F; Danesh, J; Hayward, C; Howson, JMM; Laakso, M; Lakatta, EG; Langenberg, C; Melander, O; Mook-Kanamori, DO; Palmer, CNA; Risch, L; Scott, RA; Scott, RJ; Sever, P; Spector, TD; van der Harst, P; Wareham, NJ; Zeggini, E; Levy, D; Munroe, PB; Newton-Cheh, C; Brown, MJ; Metspalu, A; Hung, AM; O'Donnell, CJ; Edwards, TL; Program, Million Veteran; Psaty, BM; Tzoulaki, I; Barnes, MR; Wain, LV; Elliott, P; Caulfield, MJ.

In: Nature Genetics, Vol. 50, No. 10, 2018, p. 1412-1425.

Research output: Contribution to journal › Article › peer-review

Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FL, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Velez Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, WY, Luan, J, Mangino, M, Oldmeadow, C, Prins, BP, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Zhao, JH, Amouyel, P, Connell, J, de Mutsert, R, Doney, ASF, Farrall, M, Menni, C, Morris, AD, Noordam, R, Paré, G, Poulter, NR, Shields, DC, Stanton, A, Thom, S, Abecasis, G, Amin, N, Arking, DE, Ayers, KL, Barbieri, CM, Batini, C, Bis, JC, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, DI, Bottinger, EP, Braund, PS, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, JC, Chauhan, G, Ciullo, M, Cocca, M, Collins, F, Cordell, HJ, Davies, G, Borst, MH, Geus, EJ, Deary, IJ, Deelen, J, Del Greco M, F, Demirkale, CY, Dörr, M, Ehret, GB, Elosua, R, Enroth, S, Erzurumluoglu, AM, Ferreira, T, Frånberg, M, Franco, OH, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, AJ, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, TB, Harris, SE, Hartman, CA, Havulinna, AS, Hicks, AA, Hofer, E, Hofman, A, Hottenga, JJ, Huffman, JE, Hwang, SJ, Ingelsson, E, James, A, Jansen, R, Jarvelin, MR, Joehanes, R, Johansson, Å, Johnson, AD, Joshi, PK, Jousilahti, P, Jukema, JW, Jula, A, Kähönen, M, Kathiresan, S, Keavney, BD, Khaw, KT, Knekt, P, Knight, J, Kolcic, I, Kooner, JS, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, LJ, Lehne, B, Lehtimäki, T, Liewald, DCM, Lin, L, Lind, L, Lindgren, CM, Liu, Y, Loos, RJF, Lopez, LM, Lu, Y, Lyytikäinen, LP, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, AP, Morrison, AC, Munson, PJ, Nalls, MA, Nandakumar, P, Nelson, CP, Niiranen, T, Nolte, IM, Nutile, T, Oldehinkel, AJ, Oostra, BA, O'Reilly, PF, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, BWJH, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Nguyen, QT, Raitakari, OT, Ren, M, Rettig, R, Rice, K, Ridker, PM, Ried, JS, Riese, H, Ripatti, S, Robino, A, Rose, LM, Rotter, JI, Rudan, I, Ruggiero, D, Saba, Y, Sala, CF, Salomaa, V, Samani, NJ, Sarin, AP, Schmidt, R, Schmidt, H, Shrine, N, Siscovick, D, Smith, AV, Snieder, H, Sõber, S, Sorice, R, Starr, JM, Stott, DJ, Strachan, DP, Strawbridge, RJ, Sundström, J, Swertz, MA, Taylor, KD, Teumer, A, Tobin, MD, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, AG, Vaez, A, van der Most, PJ, van Duijn, CM, Vergnaud, AC, Verwoert, GC, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, SH, Willemsen, G, Wilson, JF, Wright, AF, Yao, J, Zemunik, T, Zhang, W, Attia, JR, Butterworth, AS, Chasman, DI, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, JMM, Laakso, M, Lakatta, EG, Langenberg, C, Melander, O, Mook-Kanamori, DO, Palmer, CNA, Risch, L, Scott, RA, Scott, RJ, Sever, P, Spector, TD, van der Harst, P, Wareham, NJ, Zeggini, E, Levy, D, Munroe, PB, Newton-Cheh, C, Brown, MJ, Metspalu, A, Hung, AM, O'Donnell, CJ, Edwards, TL, Program, MV, Psaty, BM, Tzoulaki, I, Barnes, MR, Wain, LV, Elliott, P & Caulfield, MJ 2018, 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits', Nature Genetics, vol. 50, no. 10, pp. 1412-1425. https://doi.org/10.1038/s41588-018-0205-x

Evangelou, E ; Warren, HR ; Mosen-Ansorena, D ; Mifsud, B ; Pazoki, R ; Gao, H ; Ntritsos, G ; Dimou, N ; Cabrera, CP ; Karaman, I ; Ng, FL ; Evangelou, M ; Witkowska, K ; Tzanis, E ; Hellwege, JN ; Giri, A ; Velez Edwards, DR ; Sun, YV ; Cho, K ; Gaziano, JM ; Wilson, PWF ; Tsao, PS ; Kovesdy, CP ; Esko, T ; Mägi, R ; Milani, L ; Almgren, P ; Boutin, T ; Debette, S ; Ding, J ; Giulianini, F ; Holliday, EG ; Jackson, AU ; Li-Gao, R ; Lin, WY ; Luan, J ; Mangino, M ; Oldmeadow, C ; Prins, BP ; Qian, Y ; Sargurupremraj, M ; Shah, N ; Surendran, P ; Thériault, S ; Verweij, N ; Willems, SM ; Zhao, JH ; Amouyel, P ; Connell, J ; de Mutsert, R ; Doney, ASF ; Farrall, M ; Menni, C ; Morris, AD ; Noordam, R ; Paré, G ; Poulter, NR ; Shields, DC ; Stanton, A ; Thom, S ; Abecasis, G ; Amin, N ; Arking, DE ; Ayers, KL ; Barbieri, CM ; Batini, C ; Bis, JC ; Blake, T ; Bochud, M ; Boehnke, M ; Boerwinkle, E ; Boomsma, DI ; Bottinger, EP ; Braund, PS ; Brumat, M ; Campbell, A ; Campbell, H ; Chakravarti, A ; Chambers, JC ; Chauhan, G ; Ciullo, M ; Cocca, M ; Collins, F ; Cordell, HJ ; Davies, G ; Borst, MH ; Geus, EJ ; Deary, IJ ; Deelen, J ; Del Greco M, F ; Demirkale, CY ; Dörr, M ; Ehret, GB ; Elosua, R ; Enroth, S ; Erzurumluoglu, AM ; Ferreira, T ; Frånberg, M ; Franco, OH ; Gandin, I ; Gasparini, P ; Giedraitis, V ; Gieger, C ; Girotto, G ; Goel, A ; Gow, AJ ; Gudnason, V ; Guo, X ; Gyllensten, U ; Hamsten, A ; Harris, TB ; Harris, SE ; Hartman, CA ; Havulinna, AS ; Hicks, AA ; Hofer, E ; Hofman, A ; Hottenga, JJ ; Huffman, JE ; Hwang, SJ ; Ingelsson, E ; James, A ; Jansen, R ; Jarvelin, MR ; Joehanes, R ; Johansson, Å ; Johnson, AD ; Joshi, PK ; Jousilahti, P ; Jukema, JW ; Jula, A ; Kähönen, M ; Kathiresan, S ; Keavney, BD ; Khaw, KT ; Knekt, P ; Knight, J ; Kolcic, I ; Kooner, JS ; Koskinen, S ; Kristiansson, K ; Kutalik, Z ; Laan, M ; Larson, M ; Launer, LJ ; Lehne, B ; Lehtimäki, T ; Liewald, DCM ; Lin, L ; Lind, L ; Lindgren, CM ; Liu, Y ; Loos, RJF ; Lopez, LM ; Lu, Y ; Lyytikäinen, LP ; Mahajan, A ; Mamasoula, C ; Marrugat, J ; Marten, J ; Milaneschi, Y ; Morgan, A ; Morris, AP ; Morrison, AC ; Munson, PJ ; Nalls, MA ; Nandakumar, P ; Nelson, CP ; Niiranen, T ; Nolte, IM ; Nutile, T ; Oldehinkel, AJ ; Oostra, BA ; O'Reilly, PF ; Org, E ; Padmanabhan, S ; Palmas, W ; Palotie, A ; Pattie, A ; Penninx, BWJH ; Perola, M ; Peters, A ; Polasek, O ; Pramstaller, PP ; Nguyen, QT ; Raitakari, OT ; Ren, M ; Rettig, R ; Rice, K ; Ridker, PM ; Ried, JS ; Riese, H ; Ripatti, S ; Robino, A ; Rose, LM ; Rotter, JI ; Rudan, I ; Ruggiero, D ; Saba, Y ; Sala, CF ; Salomaa, V ; Samani, NJ ; Sarin, AP ; Schmidt, R ; Schmidt, H ; Shrine, N ; Siscovick, D ; Smith, AV ; Snieder, H ; Sõber, S ; Sorice, R ; Starr, JM ; Stott, DJ ; Strachan, DP ; Strawbridge, RJ ; Sundström, J ; Swertz, MA ; Taylor, KD ; Teumer, A ; Tobin, MD ; Tomaszewski, M ; Toniolo, D ; Traglia, M ; Trompet, S ; Tuomilehto, J ; Tzourio, C ; Uitterlinden, AG ; Vaez, A ; van der Most, PJ ; van Duijn, CM ; Vergnaud, AC ; Verwoert, GC ; Vitart, V ; Völker, U ; Vollenweider, P ; Vuckovic, D ; Watkins, H ; Wild, SH ; Willemsen, G ; Wilson, JF ; Wright, AF ; Yao, J ; Zemunik, T ; Zhang, W ; Attia, JR ; Butterworth, AS ; Chasman, DI ; Conen, D ; Cucca, F ; Danesh, J ; Hayward, C ; Howson, JMM ; Laakso, M ; Lakatta, EG ; Langenberg, C ; Melander, O ; Mook-Kanamori, DO ; Palmer, CNA ; Risch, L ; Scott, RA ; Scott, RJ ; Sever, P ; Spector, TD ; van der Harst, P ; Wareham, NJ ; Zeggini, E ; Levy, D ; Munroe, PB ; Newton-Cheh, C ; Brown, MJ ; Metspalu, A ; Hung, AM ; O'Donnell, CJ ; Edwards, TL ; Program, Million Veteran ; Psaty, BM ; Tzoulaki, I ; Barnes, MR ; Wain, LV ; Elliott, P ; Caulfield, MJ. / Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics. 2018 ; Vol. 50, No. 10. pp. 1412-1425.

@article{743fe265405d4969aa4a631dc9690f45,

title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits",

abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",

author = "E Evangelou and HR Warren and D Mosen-Ansorena and B Mifsud and R Pazoki and H Gao and G Ntritsos and N Dimou and CP Cabrera and I Karaman and FL Ng and M Evangelou and K Witkowska and E Tzanis and JN Hellwege and A Giri and {Velez Edwards}, DR and YV Sun and K Cho and JM Gaziano and PWF Wilson and PS Tsao and CP Kovesdy and T Esko and R M{\"a}gi and L Milani and P Almgren and T Boutin and S Debette and J Ding and F Giulianini and EG Holliday and AU Jackson and R Li-Gao and WY Lin and J Luan and M Mangino and C Oldmeadow and BP Prins and Y Qian and M Sargurupremraj and N Shah and P Surendran and S Th{\'e}riault and N Verweij and SM Willems and JH Zhao and P Amouyel and J Connell and {de Mutsert}, R and ASF Doney and M Farrall and C Menni and AD Morris and R Noordam and G Par{\'e} and NR Poulter and DC Shields and A Stanton and S Thom and G Abecasis and N Amin and DE Arking and KL Ayers and CM Barbieri and C Batini and JC Bis and T Blake and M Bochud and M Boehnke and E Boerwinkle and DI Boomsma and EP Bottinger and PS Braund and M Brumat and A Campbell and H Campbell and A Chakravarti and JC Chambers and G Chauhan and M Ciullo and M Cocca and F Collins and HJ Cordell and G Davies and MH Borst and EJ Geus and IJ Deary and J Deelen and {Del Greco M}, F and CY Demirkale and M D{\"o}rr and GB Ehret and R Elosua and S Enroth and AM Erzurumluoglu and T Ferreira and M Fr{\aa}nberg and OH Franco and I Gandin and P Gasparini and V Giedraitis and C Gieger and G Girotto and A Goel and AJ Gow and V Gudnason and X Guo and U Gyllensten and A Hamsten and TB Harris and SE Harris and CA Hartman and AS Havulinna and AA Hicks and E Hofer and A Hofman and JJ Hottenga and JE Huffman and SJ Hwang and E Ingelsson and A James and R Jansen and MR Jarvelin and R Joehanes and {\AA} Johansson and AD Johnson and PK Joshi and P Jousilahti and JW Jukema and A Jula and M K{\"a}h{\"o}nen and S Kathiresan and BD Keavney and KT Khaw and P Knekt and J Knight and I Kolcic and JS Kooner and S Koskinen and K Kristiansson and Z Kutalik and M Laan and M Larson and LJ Launer and B Lehne and T Lehtim{\"a}ki and DCM Liewald and L Lin and L Lind and CM Lindgren and Y Liu and RJF Loos and LM Lopez and Y Lu and LP Lyytik{\"a}inen and A Mahajan and C Mamasoula and J Marrugat and J Marten and Y Milaneschi and A Morgan and AP Morris and AC Morrison and PJ Munson and MA Nalls and P Nandakumar and CP Nelson and T Niiranen and IM Nolte and T Nutile and AJ Oldehinkel and BA Oostra and PF O'Reilly and E Org and S Padmanabhan and W Palmas and A Palotie and A Pattie and BWJH Penninx and M Perola and A Peters and O Polasek and PP Pramstaller and QT Nguyen and OT Raitakari and M Ren and R Rettig and K Rice and PM Ridker and JS Ried and H Riese and S Ripatti and A Robino and LM Rose and JI Rotter and I Rudan and D Ruggiero and Y Saba and CF Sala and V Salomaa and NJ Samani and AP Sarin and R Schmidt and H Schmidt and N Shrine and D Siscovick and AV Smith and H Snieder and S S{\~o}ber and R Sorice and JM Starr and DJ Stott and DP Strachan and RJ Strawbridge and J Sundstr{\"o}m and MA Swertz and KD Taylor and A Teumer and MD Tobin and M Tomaszewski and D Toniolo and M Traglia and S Trompet and J Tuomilehto and C Tzourio and AG Uitterlinden and A Vaez and {van der Most}, PJ and {van Duijn}, CM and AC Vergnaud and GC Verwoert and V Vitart and U V{\"o}lker and P Vollenweider and D Vuckovic and H Watkins and SH Wild and G Willemsen and JF Wilson and AF Wright and J Yao and T Zemunik and W Zhang and JR Attia and AS Butterworth and DI Chasman and D Conen and F Cucca and J Danesh and C Hayward and JMM Howson and M Laakso and EG Lakatta and C Langenberg and O Melander and DO Mook-Kanamori and CNA Palmer and L Risch and RA Scott and RJ Scott and P Sever and TD Spector and {van der Harst}, P and NJ Wareham and E Zeggini and D Levy and PB Munroe and C Newton-Cheh and MJ Brown and A Metspalu and AM Hung and CJ O'Donnell and TL Edwards and Program, {Million Veteran} and BM Psaty and I Tzoulaki and MR Barnes and LV Wain and P Elliott and MJ Caulfield",

year = "2018",

doi = "10.1038/s41588-018-0205-x",

language = "English",

volume = "50",

pages = "1412--1425",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - Evangelou, E

AU - Warren, HR

AU - Mosen-Ansorena, D

AU - Mifsud, B

AU - Pazoki, R

AU - Gao, H

AU - Ntritsos, G

AU - Dimou, N

AU - Cabrera, CP

AU - Karaman, I

AU - Ng, FL

AU - Evangelou, M

AU - Witkowska, K

AU - Tzanis, E

AU - Hellwege, JN

AU - Giri, A

AU - Velez Edwards, DR

AU - Sun, YV

AU - Cho, K

AU - Gaziano, JM

AU - Wilson, PWF

AU - Tsao, PS

AU - Kovesdy, CP

AU - Esko, T

AU - Mägi, R

AU - Milani, L

AU - Almgren, P

AU - Boutin, T

AU - Debette, S

AU - Ding, J

AU - Giulianini, F

AU - Holliday, EG

AU - Jackson, AU

AU - Li-Gao, R

AU - Lin, WY

AU - Luan, J

AU - Mangino, M

AU - Oldmeadow, C

AU - Prins, BP

AU - Qian, Y

AU - Sargurupremraj, M

AU - Shah, N

AU - Surendran, P

AU - Thériault, S

AU - Verweij, N

AU - Willems, SM

AU - Zhao, JH

AU - Amouyel, P

AU - Connell, J

AU - de Mutsert, R

AU - Doney, ASF

AU - Farrall, M

AU - Menni, C

AU - Morris, AD

AU - Noordam, R

AU - Paré, G

AU - Poulter, NR

AU - Shields, DC

AU - Stanton, A

AU - Thom, S

AU - Abecasis, G

AU - Amin, N

AU - Arking, DE

AU - Ayers, KL

AU - Barbieri, CM

AU - Batini, C

AU - Bis, JC

AU - Blake, T

AU - Bochud, M

AU - Boehnke, M

AU - Boerwinkle, E

AU - Boomsma, DI

AU - Bottinger, EP

AU - Braund, PS

AU - Brumat, M

AU - Campbell, A

AU - Campbell, H

AU - Chakravarti, A

AU - Chambers, JC

AU - Chauhan, G

AU - Ciullo, M

AU - Cocca, M

AU - Collins, F

AU - Cordell, HJ

AU - Davies, G

AU - Borst, MH

AU - Geus, EJ

AU - Deary, IJ

AU - Deelen, J

AU - Del Greco M, F

AU - Demirkale, CY

AU - Dörr, M

AU - Ehret, GB

AU - Elosua, R

AU - Enroth, S

AU - Erzurumluoglu, AM

AU - Ferreira, T

AU - Frånberg, M

AU - Franco, OH

AU - Gandin, I

AU - Gasparini, P

AU - Giedraitis, V

AU - Gieger, C

AU - Girotto, G

AU - Goel, A

AU - Gow, AJ

AU - Gudnason, V

AU - Guo, X

AU - Gyllensten, U

AU - Hamsten, A

AU - Harris, TB

AU - Harris, SE

AU - Hartman, CA

AU - Havulinna, AS

AU - Hicks, AA

AU - Hofer, E

AU - Hofman, A

AU - Hottenga, JJ

AU - Huffman, JE

AU - Hwang, SJ

AU - Ingelsson, E

AU - James, A

AU - Jansen, R

AU - Jarvelin, MR

AU - Joehanes, R

AU - Johansson, Å

AU - Johnson, AD

AU - Joshi, PK

AU - Jousilahti, P

AU - Jukema, JW

AU - Jula, A

AU - Kähönen, M

AU - Kathiresan, S

AU - Keavney, BD

AU - Khaw, KT

AU - Knekt, P

AU - Knight, J

AU - Kolcic, I

AU - Kooner, JS

AU - Koskinen, S

AU - Kristiansson, K

AU - Kutalik, Z

AU - Laan, M

AU - Larson, M

AU - Launer, LJ

AU - Lehne, B

AU - Lehtimäki, T

AU - Liewald, DCM

AU - Lin, L

AU - Lind, L

AU - Lindgren, CM

AU - Liu, Y

AU - Loos, RJF

AU - Lopez, LM

AU - Lu, Y

AU - Lyytikäinen, LP

AU - Mahajan, A

AU - Mamasoula, C

AU - Marrugat, J

AU - Marten, J

AU - Milaneschi, Y

AU - Morgan, A

AU - Morris, AP

AU - Morrison, AC

AU - Munson, PJ

AU - Nalls, MA

AU - Nandakumar, P

AU - Nelson, CP

AU - Niiranen, T

AU - Nolte, IM

AU - Nutile, T

AU - Oldehinkel, AJ

AU - Oostra, BA

AU - O'Reilly, PF

AU - Org, E

AU - Padmanabhan, S

AU - Palmas, W

AU - Palotie, A

AU - Pattie, A

AU - Penninx, BWJH

AU - Perola, M

AU - Peters, A

AU - Polasek, O

AU - Pramstaller, PP

AU - Nguyen, QT

AU - Raitakari, OT

AU - Ren, M

AU - Rettig, R

AU - Rice, K

AU - Ridker, PM

AU - Ried, JS

AU - Riese, H

AU - Ripatti, S

AU - Robino, A

AU - Rose, LM

AU - Rotter, JI

AU - Rudan, I

AU - Ruggiero, D

AU - Saba, Y

AU - Sala, CF

AU - Salomaa, V

AU - Samani, NJ

AU - Sarin, AP

AU - Schmidt, R

AU - Schmidt, H

AU - Shrine, N

AU - Siscovick, D

AU - Smith, AV

AU - Snieder, H

AU - Sõber, S

AU - Sorice, R

AU - Starr, JM

AU - Stott, DJ

AU - Strachan, DP

AU - Strawbridge, RJ

AU - Sundström, J

AU - Swertz, MA

AU - Taylor, KD

AU - Teumer, A

AU - Tobin, MD

AU - Tomaszewski, M

AU - Toniolo, D

AU - Traglia, M

AU - Trompet, S

AU - Tuomilehto, J

AU - Tzourio, C

AU - Uitterlinden, AG

AU - Vaez, A

AU - van der Most, PJ

AU - van Duijn, CM

AU - Vergnaud, AC

AU - Verwoert, GC

AU - Vitart, V

AU - Völker, U

AU - Vollenweider, P

AU - Vuckovic, D

AU - Watkins, H

AU - Wild, SH

AU - Willemsen, G

AU - Wilson, JF

AU - Wright, AF

AU - Yao, J

AU - Zemunik, T

AU - Zhang, W

AU - Attia, JR

AU - Butterworth, AS

AU - Chasman, DI

AU - Conen, D

AU - Cucca, F

AU - Danesh, J

AU - Hayward, C

AU - Howson, JMM

AU - Laakso, M

AU - Lakatta, EG

AU - Langenberg, C

AU - Melander, O

AU - Mook-Kanamori, DO

AU - Palmer, CNA

AU - Risch, L

AU - Scott, RA

AU - Scott, RJ

AU - Sever, P

AU - Spector, TD

AU - van der Harst, P

AU - Wareham, NJ

AU - Zeggini, E

AU - Levy, D

AU - Munroe, PB

AU - Newton-Cheh, C

AU - Brown, MJ

AU - Metspalu, A

AU - Hung, AM

AU - O'Donnell, CJ

AU - Edwards, TL

AU - Program, Million Veteran

AU - Psaty, BM

AU - Tzoulaki, I

AU - Barnes, MR

AU - Wain, LV

AU - Elliott, P

AU - Caulfield, MJ

PY - 2018

Y1 - 2018

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Article

VL - 50

SP - 1412

EP - 1425

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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