Abstract
Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.
| Original language | English |
|---|---|
| Pages (from-to) | 292-296 |
| Number of pages | 5 |
| Journal | European Journal of Human Genetics |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Aging
- Apolipoproteins
- Human longevity
- Polymorphism
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. / Bonafè, Massimiliano; Marchegiani, Francesca; Cardelli, Maurizio; Olivieri, Fabiola; Cavallone, Luca; Giovagnetti, Simona; Pieri, Carlo; Marra, Maurizio; Antonicelli, Roberto; Troiano, Leonarda; Gueresi, Paola; Passeri, Giovanni; Berardelli, Maurizio; Paolisso, Giuseppe; Barbieri, Michelangela; Tesei, Silvia; Lisa, Rosemarie; De Benedictis, Giovanna; Franceschi, Claudio.
In: European Journal of Human Genetics, Vol. 10, No. 5, 2002, p. 292-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
AU - Bonafè, Massimiliano
AU - Marchegiani, Francesca
AU - Cardelli, Maurizio
AU - Olivieri, Fabiola
AU - Cavallone, Luca
AU - Giovagnetti, Simona
AU - Pieri, Carlo
AU - Marra, Maurizio
AU - Antonicelli, Roberto
AU - Troiano, Leonarda
AU - Gueresi, Paola
AU - Passeri, Giovanni
AU - Berardelli, Maurizio
AU - Paolisso, Giuseppe
AU - Barbieri, Michelangela
AU - Tesei, Silvia
AU - Lisa, Rosemarie
AU - De Benedictis, Giovanna
AU - Franceschi, Claudio
PY - 2002
Y1 - 2002
N2 - Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.
AB - Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.
KW - Aging
KW - Apolipoproteins
KW - Human longevity
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=18444377055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18444377055&partnerID=8YFLogxK
U2 - 10.1038/sj.ejhg.5200806
DO - 10.1038/sj.ejhg.5200806
M3 - Article
C2 - 12082503
AN - SCOPUS:18444377055
VL - 10
SP - 292
EP - 296
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 5
ER -