Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians

Massimiliano Bonafè, Francesca Marchegiani, Maurizio Cardelli, Fabiola Olivieri, Luca Cavallone, Simona Giovagnetti, Carlo Pieri, Maurizio Marra, Roberto Antonicelli, Leonarda Troiano, Paola Gueresi, Giovanni Passeri, Maurizio Berardelli, Giuseppe Paolisso, Michelangela Barbieri, Silvia Tesei, Rosemarie Lisa, Giovanna De Benedictis, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalEuropean Journal of Human Genetics
Volume10
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Aging
  • Apolipoproteins
  • Human longevity
  • Polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)

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    Bonafè, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., Gueresi, P., Passeri, G., Berardelli, M., Paolisso, G., Barbieri, M., Tesei, S., Lisa, R., De Benedictis, G., & Franceschi, C. (2002). Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. European Journal of Human Genetics, 10(5), 292-296. https://doi.org/10.1038/sj.ejhg.5200806