Genetic analysis of the kinome and phosphatome in cancer

S. Arena, S. Benvenuti, A. Bardelli

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Protein phosphorylation is a well-characterized biochemical process for reversible regulation of protein activity. Protein kinases and protein phosphatases are the key complementary players in this process, and through their coordinated activity cell homeostasis is tightly controlled. If these enzymes display aberrant activity, cells may undergo unrestrained growth, thus giving rise to complex diseases such as cancer. The technological platform gathered during the Human Genome Project recently allowed the systematic identification of the genetic alterations present in the kinase (the kinome) and the phosphatase (the phosphatome) gene families. These studies suggest that most if not all human tumors carry genetic alterations in at least one phosphatase or kinase gene. Here we integrate the biochemical knowledge on the properties of these molecules with the information collected through their systematic genetic analysis in cancer. We also analyze why the molecular profiling of the kinome and phosphatome in individual cancers is revolutionizing basic and clinical oncology.

Original languageEnglish
Pages (from-to)2092-2099
Number of pages8
JournalCellular and Molecular Life Sciences
Volume62
Issue number18
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Genes
Phosphoric Monoester Hydrolases
Phosphotransferases
Neoplasms
Phosphorylation
Biochemical Phenomena
Oncology
Phosphoprotein Phosphatases
Human Genome Project
Protein Kinases
Medical Oncology
Tumors
Proteins
Molecules
Homeostasis
Enzymes
Growth

Keywords

  • Cancer
  • Kinase
  • Mutational analysis
  • Phosphatase
  • Phosphorylation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Genetic analysis of the kinome and phosphatome in cancer. / Arena, S.; Benvenuti, S.; Bardelli, A.

In: Cellular and Molecular Life Sciences, Vol. 62, No. 18, 09.2005, p. 2092-2099.

Research output: Contribution to journalArticle

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