Genetic and environmental factors affecting birth size variation: A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Yoshie Yokoyama, Aline Jelenkovic, Yoon Mi Hur, Reijo Sund, Corrado Fagnani, Maria A. Stazi, Sonia Brescianini, Fuling Ji, Feng Ning, Zengchang Pang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Esther Rebato, John L. Hopper, Tessa L. Cutler, Kimberly J. Saudino, Tracy L. Nelson, Keith E. Whitfield, Robin P. CorleyBrooke M. Huibregtse, Catherine A. Derom, Robert F. Vlietinck, Ruth J.F. Loos, Clare H. Llewellyn, Abigail Fisher, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F. Krueger, Matt McGue, Shandell Pahlen, Meike Bartels, Catharina E.M. Van Beijsterveldt, Gonneke Willemsen, Jennifer R. Harris, Ingunn Brandt, Thomas S. Nilsen, Jeffrey M. Craig, Richard Saffery, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Claire M.A. Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Finn Rasmussen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.

Original languageEnglish
Pages (from-to)1195-1206
Number of pages12
JournalInternational Journal of Epidemiology
Volume47
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

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Parturition
Gestational Age
Weights and Measures
Far East
North America
Dizygotic Twins
Monozygotic Twins

Keywords

  • Birth length
  • Birthweight
  • Genetics
  • Ponderal index
  • Pooled studies
  • Twins

ASJC Scopus subject areas

  • Epidemiology

Cite this

Genetic and environmental factors affecting birth size variation : A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts. / Yokoyama, Yoshie; Jelenkovic, Aline; Hur, Yoon Mi; Sund, Reijo; Fagnani, Corrado; Stazi, Maria A.; Brescianini, Sonia; Ji, Fuling; Ning, Feng; Pang, Zengchang; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Rebato, Esther; Hopper, John L.; Cutler, Tessa L.; Saudino, Kimberly J.; Nelson, Tracy L.; Whitfield, Keith E.; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J.F.; Llewellyn, Clare H.; Fisher, Abigail; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Bartels, Meike; Van Beijsterveldt, Catharina E.M.; Willemsen, Gonneke; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Craig, Jeffrey M.; Saffery, Richard; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Haworth, Claire M.A.; Plomin, Robert; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Rasmussen, Finn.

In: International Journal of Epidemiology, Vol. 47, No. 4, 01.01.2018, p. 1195-1206.

Research output: Contribution to journalArticle

Yokoyama, Y, Jelenkovic, A, Hur, YM, Sund, R, Fagnani, C, Stazi, MA, Brescianini, S, Ji, F, Ning, F, Pang, Z, Knafo-Noam, A, Mankuta, D, Abramson, L, Rebato, E, Hopper, JL, Cutler, TL, Saudino, KJ, Nelson, TL, Whitfield, KE, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Llewellyn, CH, Fisher, A, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Krueger, RF, McGue, M, Pahlen, S, Bartels, M, Van Beijsterveldt, CEM, Willemsen, G, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D & Rasmussen, F 2018, 'Genetic and environmental factors affecting birth size variation: A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts', International Journal of Epidemiology, vol. 47, no. 4, pp. 1195-1206. https://doi.org/10.1093/ije/dyy081
Yokoyama, Yoshie ; Jelenkovic, Aline ; Hur, Yoon Mi ; Sund, Reijo ; Fagnani, Corrado ; Stazi, Maria A. ; Brescianini, Sonia ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Rebato, Esther ; Hopper, John L. ; Cutler, Tessa L. ; Saudino, Kimberly J. ; Nelson, Tracy L. ; Whitfield, Keith E. ; Corley, Robin P. ; Huibregtse, Brooke M. ; Derom, Catherine A. ; Vlietinck, Robert F. ; Loos, Ruth J.F. ; Llewellyn, Clare H. ; Fisher, Abigail ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Krueger, Robert F. ; McGue, Matt ; Pahlen, Shandell ; Bartels, Meike ; Van Beijsterveldt, Catharina E.M. ; Willemsen, Gonneke ; Harris, Jennifer R. ; Brandt, Ingunn ; Nilsen, Thomas S. ; Craig, Jeffrey M. ; Saffery, Richard ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Haworth, Claire M.A. ; Plomin, Robert ; Bayasgalan, Gombojav ; Narandalai, Danshiitsoodol ; Rasmussen, Finn. / Genetic and environmental factors affecting birth size variation : A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts. In: International Journal of Epidemiology. 2018 ; Vol. 47, No. 4. pp. 1195-1206.
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abstract = "Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.",
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author = "Yoshie Yokoyama and Aline Jelenkovic and Hur, {Yoon Mi} and Reijo Sund and Corrado Fagnani and Stazi, {Maria A.} and Sonia Brescianini and Fuling Ji and Feng Ning and Zengchang Pang and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Esther Rebato and Hopper, {John L.} and Cutler, {Tessa L.} and Saudino, {Kimberly J.} and Nelson, {Tracy L.} and Whitfield, {Keith E.} and Corley, {Robin P.} and Huibregtse, {Brooke M.} and Derom, {Catherine A.} and Vlietinck, {Robert F.} and Loos, {Ruth J.F.} and Llewellyn, {Clare H.} and Abigail Fisher and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Krueger, {Robert F.} and Matt McGue and Shandell Pahlen and Meike Bartels and {Van Beijsterveldt}, {Catharina E.M.} and Gonneke Willemsen and Harris, {Jennifer R.} and Ingunn Brandt and Nilsen, {Thomas S.} and Craig, {Jeffrey M.} and Richard Saffery and Lise Dubois and Michel Boivin and Mara Brendgen and Ginette Dionne and Frank Vitaro and Haworth, {Claire M.A.} and Robert Plomin and Gombojav Bayasgalan and Danshiitsoodol Narandalai and Finn Rasmussen",
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T1 - Genetic and environmental factors affecting birth size variation

T2 - A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

AU - Yokoyama, Yoshie

AU - Jelenkovic, Aline

AU - Hur, Yoon Mi

AU - Sund, Reijo

AU - Fagnani, Corrado

AU - Stazi, Maria A.

AU - Brescianini, Sonia

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Rebato, Esther

AU - Hopper, John L.

AU - Cutler, Tessa L.

AU - Saudino, Kimberly J.

AU - Nelson, Tracy L.

AU - Whitfield, Keith E.

AU - Corley, Robin P.

AU - Huibregtse, Brooke M.

AU - Derom, Catherine A.

AU - Vlietinck, Robert F.

AU - Loos, Ruth J.F.

AU - Llewellyn, Clare H.

AU - Fisher, Abigail

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Krueger, Robert F.

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Bartels, Meike

AU - Van Beijsterveldt, Catharina E.M.

AU - Willemsen, Gonneke

AU - Harris, Jennifer R.

AU - Brandt, Ingunn

AU - Nilsen, Thomas S.

AU - Craig, Jeffrey M.

AU - Saffery, Richard

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Haworth, Claire M.A.

AU - Plomin, Robert

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Rasmussen, Finn

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.

AB - Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.

KW - Birth length

KW - Birthweight

KW - Genetics

KW - Ponderal index

KW - Pooled studies

KW - Twins

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U2 - 10.1093/ije/dyy081

DO - 10.1093/ije/dyy081

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VL - 47

SP - 1195

EP - 1206

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

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