Genetic and Epigenetic Mechanisms in Multiple Myeloma

Michela Frenquelli, Giovanni Tonon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple myeloma (MM) is a malignant disorder due to clonal proliferation of plasma cells in the bone marrow in association with elevated serum or urine monoclonal paraprotein levels. MM is associated, particularly in the most advanced stages of the disease, with severe complication, like lytic bone lesion, anemia, immunodeficiency and renal failure. Despite advances in the understanding of the disease and the use of high-dose chemotherapy, MM remains an incurable disease. From a genetic standpoint, MM development is a multistep process characterized by the presence of a series of chromosomal abnormalities and complex translocations, involving known oncogenes and tumor-suppressor genes. Genomic aberrations are present with increasing frequency as disease progresses. There is an increasing evidence that, in addition to genomic abnormalities, epigenetic dysregulation plays a pivotal role in MM development, making the picture even more complex.

Original languageEnglish
Title of host publicationMultiple Myeloma - A New Era of Treatment Strategies
PublisherBentham Science Publishers Ltd.
Pages58-72
Number of pages15
ISBN (Print)9781608056095
DOIs
Publication statusPublished - 2012

Keywords

  • Epigenetics
  • FGFR3
  • Histones
  • Hyperdiploidy
  • IRF4
  • MAF
  • MicroRNAs
  • Minimal common regions
  • MMSET
  • Myc
  • NFΚB
  • Non-hyperdiploidy
  • Ras
  • TP53
  • Translocations

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Frenquelli, M., & Tonon, G. (2012). Genetic and Epigenetic Mechanisms in Multiple Myeloma. In Multiple Myeloma - A New Era of Treatment Strategies (pp. 58-72). Bentham Science Publishers Ltd.. https://doi.org/10.2174/978160805297411201010058