Genetic and epigenetic mechanisms in the early development of the vascular system

Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

The cardiovascular system plays a critical role in vertebrate development and homeostasis. Vascular development is a highly organized sequence of events that requires the correct spatial and temporal expression of specific sets of genes leading to the development of a primary vascular network. There have been intensive efforts to determine the molecular mechanisms regulating vascular growth and development, and much of the rationale for this has stemmed from the increasing clinical importance and therapeutic potential of modulating vascular formation during various disease states.

Original languageEnglish
Pages (from-to)139-152
Number of pages14
JournalJournal of Anatomy
Volume208
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

cardiovascular system
homeostasis
blood vessels
Epigenomics
epigenetics
growth and development
Blood Vessels
early development
vertebrate
gene
Cardiovascular System
Growth and Development
Vertebrates
Homeostasis
vertebrates
therapeutics
Genes
genes
Therapeutics

Keywords

  • Angiogenesis
  • Vascular development
  • Vasculogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Genetic and epigenetic mechanisms in the early development of the vascular system. / Ribatti, Domenico.

In: Journal of Anatomy, Vol. 208, No. 2, 02.2006, p. 139-152.

Research output: Contribution to journalArticle

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