Genetic and expression profiles of cerebellar liponeurocytomas

Sonja Hostmann, Arie Perry, Guido Reifenberger, Felice Giangaspero, Herve Huang, Akira Hara, Jun Masuoka, Nikolai G. Rainov, Markus Bergmann, Frank L. Heppner, Sebastian Brandner, Leila Chimelli, Nádia Montagna, Thad Jackson, Daron G. Davis, William R. Markesbery, David W. Ellison, Roy O. Weller, Gian L. Taddei, Renato ContiMarc R. Del Bigio, Ricardo González-Cámpora, V. V. Radhakrishnan, Figen Söylemezoglu, Emmanuelle Uro-Coste, Jiang Qian, Paul Kleihues, Hiroko Ohgaki

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Cerebellar liponeurocytoma, a rare, newly identified CNS neoplasm ~of adults, is characterized by advanced neuronal/neurocytic and focal lipomatous differentiation, low proliferative potential and a favorable clinical prognosis. Despite the different age distribution and benign biological behavior, the cerebellar liponeurocytoma shares several features with the cerebellar medulloblastoma, which may include an origin from the periventricular matrix of the fourth ventricle or the external granular layer of the cerebellum. To establish the genetic profile of cerebellar liponeurocytomas, we have formed an international consortium and collected tumor samples from 20 patients. DNA sequencing revealed TP53 missense mutations in 4 (20%) of 20 cerebellar liponeurocytomas, a frequency higher than in medulloblastomas. There was no case with PTCH, APC, or β-catenin mutations, each of which may be present in subsets of medulloblastomas. Isochromosome 17q, a genetic hallmark of classic medulloblastomas, was not observed in any of the cases investigated by FISH analysis. cDNA array analyses were carried out on 4 cerebellar liponeurocytomas, 4 central neurocytomas, and 4 classic medulloblastomas. Cluster analysis of the cDNA expression data of 1176 genes grouped cerebellar liponeurocytomas close to central neurocytomas, but distinct from medulloblastomas. These results suggest cerebellar liponeurocytoma as a distinct tumor entity that is genetically different from medulloblastoma. Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different.

Original languageEnglish
Pages (from-to)281-289
Number of pages9
JournalBrain Pathology
Volume14
Issue number3
Publication statusPublished - Jul 2004

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Medulloblastoma
Neurocytoma
Oligonucleotide Array Sequence Analysis
Isochromosomes
Fourth Ventricle
Catenins
Neoplasms
Mutation
Neocortex
Age Distribution
Missense Mutation
DNA Sequence Analysis
Cerebellum
Cluster Analysis
Complementary DNA
Genes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

Hostmann, S., Perry, A., Reifenberger, G., Giangaspero, F., Huang, H., Hara, A., ... Ohgaki, H. (2004). Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathology, 14(3), 281-289.

Genetic and expression profiles of cerebellar liponeurocytomas. / Hostmann, Sonja; Perry, Arie; Reifenberger, Guido; Giangaspero, Felice; Huang, Herve; Hara, Akira; Masuoka, Jun; Rainov, Nikolai G.; Bergmann, Markus; Heppner, Frank L.; Brandner, Sebastian; Chimelli, Leila; Montagna, Nádia; Jackson, Thad; Davis, Daron G.; Markesbery, William R.; Ellison, David W.; Weller, Roy O.; Taddei, Gian L.; Conti, Renato; Del Bigio, Marc R.; González-Cámpora, Ricardo; Radhakrishnan, V. V.; Söylemezoglu, Figen; Uro-Coste, Emmanuelle; Qian, Jiang; Kleihues, Paul; Ohgaki, Hiroko.

In: Brain Pathology, Vol. 14, No. 3, 07.2004, p. 281-289.

Research output: Contribution to journalArticle

Hostmann, S, Perry, A, Reifenberger, G, Giangaspero, F, Huang, H, Hara, A, Masuoka, J, Rainov, NG, Bergmann, M, Heppner, FL, Brandner, S, Chimelli, L, Montagna, N, Jackson, T, Davis, DG, Markesbery, WR, Ellison, DW, Weller, RO, Taddei, GL, Conti, R, Del Bigio, MR, González-Cámpora, R, Radhakrishnan, VV, Söylemezoglu, F, Uro-Coste, E, Qian, J, Kleihues, P & Ohgaki, H 2004, 'Genetic and expression profiles of cerebellar liponeurocytomas', Brain Pathology, vol. 14, no. 3, pp. 281-289.
Hostmann S, Perry A, Reifenberger G, Giangaspero F, Huang H, Hara A et al. Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathology. 2004 Jul;14(3):281-289.
Hostmann, Sonja ; Perry, Arie ; Reifenberger, Guido ; Giangaspero, Felice ; Huang, Herve ; Hara, Akira ; Masuoka, Jun ; Rainov, Nikolai G. ; Bergmann, Markus ; Heppner, Frank L. ; Brandner, Sebastian ; Chimelli, Leila ; Montagna, Nádia ; Jackson, Thad ; Davis, Daron G. ; Markesbery, William R. ; Ellison, David W. ; Weller, Roy O. ; Taddei, Gian L. ; Conti, Renato ; Del Bigio, Marc R. ; González-Cámpora, Ricardo ; Radhakrishnan, V. V. ; Söylemezoglu, Figen ; Uro-Coste, Emmanuelle ; Qian, Jiang ; Kleihues, Paul ; Ohgaki, Hiroko. / Genetic and expression profiles of cerebellar liponeurocytomas. In: Brain Pathology. 2004 ; Vol. 14, No. 3. pp. 281-289.
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AU - Perry, Arie

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AU - Giangaspero, Felice

AU - Huang, Herve

AU - Hara, Akira

AU - Masuoka, Jun

AU - Rainov, Nikolai G.

AU - Bergmann, Markus

AU - Heppner, Frank L.

AU - Brandner, Sebastian

AU - Chimelli, Leila

AU - Montagna, Nádia

AU - Jackson, Thad

AU - Davis, Daron G.

AU - Markesbery, William R.

AU - Ellison, David W.

AU - Weller, Roy O.

AU - Taddei, Gian L.

AU - Conti, Renato

AU - Del Bigio, Marc R.

AU - González-Cámpora, Ricardo

AU - Radhakrishnan, V. V.

AU - Söylemezoglu, Figen

AU - Uro-Coste, Emmanuelle

AU - Qian, Jiang

AU - Kleihues, Paul

AU - Ohgaki, Hiroko

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