Fibrinogen storage in liver cells can occur under three different morphological inclusions. Type I contain all three fibrinogen chains (Aα, Bβ, and γ) as well as D and E fragments, whereas type H and III lack Bβ as well as D and E fragments. Patients with type I inclusions carry a point mutation (γ284 Gly-Arg). The mutation is not present in patients with type H and III inclusions. These results appear to suggest that the three various phenotypic expressions (i.e., morphological variants) reflect different genetical abnormalities of fibrinogen.
|Number of pages||4|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 2001|
- Liver disease
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)