Genetic and metabolic risk factors for the development of microangiopathic complications of type 1 diabetes mellitus (DM)

A. E. Pontiroli, A. Calderara, L. Bonisolli

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Late complications now represent the most important reasons for mortality and disability in diabetic patients; especially microangiopathic complications, retinopathy (RT), and nephropathy (NP) in patients with type 1 DM. According to Deckert et al NP accounts for about 30% of deaths in patients with DM beginning before the age of 31. In England, when considering all age groups, DM accounts for blindness in 13.1% of men, and for 18.1% in women. However it is a common experience that not all patients develop a similar degree of complications after the same duration of disease; this has led to suppose that other factors, besides metabolic control, are involved in the development of late complications. The first aim of this study was to compare the occurrence of some genetic markers [chlorpropamide alcohol flush (CPAF), acetylator phenotype (AP), family history (FH) of diabetes and associated diseases, ABO and Rh blood groups] in type 1 diabetics and in a group of helathy controls; another aim was to evaluate the role of these genetic markers, together with metabolic control in the development of late complications of DM.

Original languageEnglish
Pages (from-to)1487-1490
Number of pages4
JournalTransplantation Proceedings
Issue number6
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Surgery
  • Transplantation

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