Genetic and pathologic significance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa

A. Cianciulli, M. Cosimelli, R. Marzano, R. Merola, G. Piperno, I. Sperduti, F. De La Iglesia, G. Leonardo, F. Graziano, R. Mancini, F. Guadagni

Research output: Contribution to journalArticle

Abstract

Among chromosome defects in colon cancer, deletions in 1p, 17p, and 18q have been reported as frequent events. To verify this, we investigated 1p, 17p, and 18q aneusomy in 60 colorectal cancers and their surrounding mucosa by means of fluorescence in situ hybridization (FISH). We also evaluated ERBB2 gene (alias HER-2/neu) amplification in a subset of tumors. The genetic picture in tumors was correlated with chromosomal alterations in normal colonic mucosae, as well with clinicopathologic variables. A population of cells in morphologically normal epithelium possesses genetic aberrations common to those in colon cancer, although in different percentages. No significant difference emerged in terms of fraction of nuclei with 17p monosomy between primary tumors and distal mucosal samples. Of tumor samples aneusomic for the three chromosomes, 58.3% also showed aneusomy in related normal colonic mucosa. In neoplastic samples, significant correlation existed between 1p aneusomy and mucosal component (P

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume151
Issue number1
DOIs
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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