Genetic association study between migraine and genes regulating dopamine metabolism

P. Montagna, P. Cortelli, L. Monad, M. L. Valentino, S. Cevoli, G. Pierangeli, S. Sortant, M. Mochi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Studies conducted in populations of patients affected with migraine with (MA) and without aura (MO) have shown significant genetic associations, with polymorphisms in genes coding for dopamine (DA) receptors, in particular the DRD2 receptor, thus confirming the role of DA in the pathogenesis of migraine. Such studies have been disproved in other migraine populations. Therefore, we conducted a genetic association study between MO and MA and several genes regulating DA metabolism: receptors DRD2 and DRD3, MAO-A and COMT enzymes which regulate DA catabolism. Material and methods. In all, 67 patients with MO, 86 patients with MA and 68 controls, all unrelated, underwent DNA characterization with 4 markers: DRD2 NcoI, DRD3 Msc1, COMT N1aIII, and MAO-A EcoRV (genes localized on the 11, 3, 22 and X chromosome, respectively). Allelic frequencies were tested by means of of the Χ2 test and by the EH program, assuming an autosomal dominant transmission model and penetrance = 0.6. Results. No significant difference was observed between MA, MO and controls for any of the 4 markers. For MAO-A, analysis, performed separately for males and females, gave a trend for significance only in the case of males and MO, but numbers were small. Conclusions. Our results do not show any genetic association between MO, MA and DRD2, DRD3 and MAO-A and COMT genes.

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number4 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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