Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C

Johannes R. Hov, Ana Lleo, Carlo Selmi, Bente Woldseth, Luca Fabris, Mario Strazzabosco, Tom H. Karlsen, Pietro Invernizzi

Research output: Contribution to journalArticle

Abstract

Background & Aims: The HLA complex on chromosome 6p21 is firmly established as a risk locus for primary sclerosing cholangitis (PSC). We aimed to exploit genetic differences between Northern Europe and Italy in an attempt to define a causative locus in this genetic region. Methods: Seventy-eight North-Italian PSC patients and 79 controls were included. We performed sequencing-based genotyping of HLA-C, HLA-B, and HLA-DRB1. The major histocompatibility chain-related A (MICA) transmembrane microsatellite was analysed using PCR fragment length determination. The tumour necrosis factor-alpha (TNF-α)-308G→A polymorphism was genotyped with TaqMan®. Allele frequencies were compared with Chi-square tests. Uncorrected p-values

Original languageEnglish
Pages (from-to)712-717
Number of pages6
JournalJournal of Hepatology
Volume52
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • HLA
  • Killer immunoglobulin-like receptors
  • Natural killer cells
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C'. Together they form a unique fingerprint.

  • Cite this