Genetic contribution to carotid vascular disease in patients with systemic lupus erythematosus

Bianca Marasini, Marco Massarotti, Marco De Monti, Maddalena Erario, Giorgio Ghilardi, Maria Luisa Biondi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We investigated whether stromelysin, a candidate gene in atherogenesis, plays a role in atherogenesis of systemic lupus erythematosus (SLE), a leading cause of mortality in SLE. Patients and Methods: A genetic study using polymorphism located in the promoter region of stromelysin was performed in 55 Italian patients with SLE. Carotid intimal-medial thickness (IMT) was evaluated by B mode ultrasonography. Results: All patients with an "abnormal" (≥0.9 mm) IMT carried at least one 6A allele, and the degree of IMT was significantly greater in patients carrying at least one 6A allele (0.63±0.22 vs 0.43±0.04 mm, 5A/6A + 6A/6A vs 5A/5A, p=0.018). Conclusion: Our data show that polymorphism of stromelysin promoter may be relevant for SLE-related cardiovascular disease.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalJournal of Clinical Immunology
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Atherosclerosis
  • Carotid intimal-medial thickness
  • Stromelysin polymorphism
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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