Genetic control of IL-1β production and inflammatory response by the mouse Irm1 locus

Francisca Vorraro, Antonella Galvan, Wafa Hanna Koury Cabrera, Patricia Santos Carneiro, Orlando Garcia Ribeiro, Marcelo De Franco, Nancy Starobinas, José Ricardo Jensen, Michel Seman, Tommaso A. Dragani, Olga Célia Martinez Ibañez

Research output: Contribution to journalArticle

Abstract

Genome-wide linkage analysis using single nucleotide polymorphism arrays was carried out in pedigrees of mice differing in the extent of acute inflammatory response (AIRmax or AIRmin). The AIR phenotype was determined by quantifying the number of infiltrating cells in the 24-h exudate induced by Biogel P-100 s.c. injection and by ex vivo IL-1β production by leukocytes stimulated with LPS and ATP. We mapped the major inflammatory response modulator 1 locus on chromosome 7, at the 1-logarithm of odds (LOD) confidence interval from 116.75 to 139.75 Mb, linked to the number of infiltrating cells (LOD = 3.61) through the production of IL-1β (LOD = 9.35). Of several interesting candidate genes mapping to the inflammatory response modulator 1 locus, 28 of these were differentially expressed in the bone marrow of AIRmax and AIRmin mice. These findings represent a step toward the identification of the genes underlying this complex phenotype.

Original languageEnglish
Pages (from-to)1616-1621
Number of pages6
JournalJournal of Immunology
Volume185
Issue number3
DOIs
Publication statusPublished - Aug 1 2010

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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    Vorraro, F., Galvan, A., Cabrera, W. H. K., Carneiro, P. S., Ribeiro, O. G., De Franco, M., Starobinas, N., Jensen, J. R., Seman, M., Dragani, T. A., & Ibañez, O. C. M. (2010). Genetic control of IL-1β production and inflammatory response by the mouse Irm1 locus. Journal of Immunology, 185(3), 1616-1621. https://doi.org/10.4049/jimmunol.1000358