Genetic correlates of protection against HIV infection: The ally within

L. Piacentini, M. Biasin, C. Fenizia, M. Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract. Piacentini L, Biasin M, Fenizia C, Clerici M (University of Milan; and Don C. Gnocchi ONLUS Foundation IRCCS; Milan, Italy). Genetic correlates of protection against HIV infection:the ally within (Review). J Intern Med 2008; 265: 110-124. Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.

Original languageEnglish
Pages (from-to)110-124
Number of pages15
JournalJournal of Internal Medicine
Volume265
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Elite controllers
  • Exposed uninfected individuals
  • Exposed-seronegative individuals
  • Genetic correlates
  • HIV
  • Long-term non progressors

ASJC Scopus subject areas

  • Internal Medicine

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