Genetic correlates of protection against HIV infection: The ally within

L. Piacentini; M. Biasin; C. Fenizia; M. Clerici

doi:10.1111/j.1365-2796.2008.02041.x

Genetic correlates of protection against HIV infection: The ally within

L. Piacentini, M. Biasin, C. Fenizia, M. Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract. Piacentini L, Biasin M, Fenizia C, Clerici M (University of Milan; and Don C. Gnocchi ONLUS Foundation IRCCS; Milan, Italy). Genetic correlates of protection against HIV infection:the ally within (Review). J Intern Med 2008; 265: 110-124. Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.

Original language	English
Pages (from-to)	110-124
Number of pages	15
Journal	Journal of Internal Medicine
Volume	265
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2796.2008.02041.x
Publication status	Published - Jan 2009

Keywords

Elite controllers
Exposed uninfected individuals
Exposed-seronegative individuals
Genetic correlates
HIV
Long-term non progressors

ASJC Scopus subject areas

Internal Medicine

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AB - Abstract. Piacentini L, Biasin M, Fenizia C, Clerici M (University of Milan; and Don C. Gnocchi ONLUS Foundation IRCCS; Milan, Italy). Genetic correlates of protection against HIV infection:the ally within (Review). J Intern Med 2008; 265: 110-124. Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.

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