Genetic determinants of quantitative traits associated with cardiovascular disease risk

Božena Smolková, Stefano Bonassi, Verona Buociková, Mária Dušinská, Alexandra Horská, Daniel Kuba, Zuzana Džupinková, Katarína Rašlová, Juraj Gašparovič, Ivan Slíž, Marcello Ceppi, Branislav Vohnout, Ladislava Wsólová, Katarína Volkovová

Research output: Contribution to journalArticlepeer-review

Abstract

Established risk factors for cardiovascular diseases (CVD) may be moderated by genetic variants. In 2403 unrelated individuals from general practice (mean age 40.5 years), we evaluated the influence of 15 variants in 12 candidate genes on quantitative traits (QT) associated with CVD (body mass index, abdominal obesity, glucose, serum lipids, and blood pressure). Prior to multiple testing correction, univariate analysis associated APOE rs429358, rs7412 and ATG16L1 rs2241880 variants with serum lipid levels, while LEPR rs1137100 and ATG16L1 rs2241880 variants were linked to obesity related QTs. After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. APOE rs429358 variant almost tripled the risk in homozygous subjects (OR. =. 2.97; 95% CI 1.09-8.10, p

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume778
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Candidate gene
  • Cardiovascular disease
  • Genetic susceptibility
  • Quantitative trait
  • Risk factor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

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