Genetic differences in daily rhythms of pain sensivity in mice

Claudio Castellano, Stefano Puglisi-Allegra, Paolo Renzi, Alberto Oliverio

Research output: Contribution to journalArticlepeer-review


A dark phase increase in pain sensitivity was evident in C57BL/6 inbred mice. On the contrary, Swiss mice are characterized by decreased nocturnal pain sensitivity. The latter finding is in agreement with a number of previous studies based on albino mice. However, our findings indicate that (1) nocturnal decreased pain sensitivity is not the rule in the mouse and (2) large differences are evident when the onset in peak nocturnal analgesia is considered.

Original languageEnglish
Pages (from-to)91-92
Number of pages2
JournalPharmacology, Biochemistry and Behavior
Issue number1
Publication statusPublished - 1985


  • Analgesia
  • Circadian rhythms
  • Mice
  • Opioid peptides
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology


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