Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism

Alessandro Serretti, Francesco Benedetti, Laura Mandelli, Cristina Lorenzi, Adele Pirovano, Cristina Colombo, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P=0.0001), middle (P=0.0009), and early (P=0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P= 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume121 B
Issue number1
Publication statusPublished - Aug 15 2003

Keywords

  • Bipolar disorder
  • Circadian rhythm
  • CLOCK gene
  • Insomnia
  • Major depressive disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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