TY - JOUR
T1 - Genetic dynamics in untreated CLL patients with either stable or progressive disease
T2 - a longitudinal study
AU - Ramassone, Alice
AU - D'Argenio, Andrea
AU - Veronese, Angelo
AU - Basti, Alessio
AU - Soliman, Shimaa Hassan AbdelAziz
AU - Volinia, Stefano
AU - Bassi, Cristian
AU - Pagotto, Sara
AU - Ferracin, Manuela
AU - Lupini, Laura
AU - Saccenti, Elena
AU - Balatti, Veronica
AU - Pepe, Felice
AU - Rassenti, Laura Z
AU - Innocenti, Idanna
AU - Autore, Francesco
AU - Marzetti, Laura
AU - Mariani-Costantini, Renato
AU - Kipps, Thomas J
AU - Negrini, Massimo
AU - Laurenti, Luca
AU - Visone, Rosa
PY - 2019/11/19
Y1 - 2019/11/19
N2 - Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
AB - Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
U2 - 10.1186/s13045-019-0802-x
DO - 10.1186/s13045-019-0802-x
M3 - Article
C2 - 31744508
VL - 12
SP - 114
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
SN - 1756-8722
IS - 1
ER -