Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study

Alice Ramassone, Andrea D'Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan AbdelAziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini, Elena Saccenti, Veronica Balatti, Felice Pepe, Laura Z Rassenti, Idanna Innocenti, Francesco Autore, Laura Marzetti, Renato Mariani-Costantini, Thomas J Kipps, Massimo NegriniLuca Laurenti, Rosa Visone

Research output: Contribution to journalArticlepeer-review

Abstract

Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.

Original languageEnglish
Pages (from-to)114
JournalJournal of hematology & oncology
Volume12
Issue number1
DOIs
Publication statusPublished - Nov 19 2019

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