Abstract
Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.
| Original language | English |
|---|---|
| Pages (from-to) | 225-232 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 57 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Genetic effects of crocidolite asbestos in Chinese hamster lung cells. / Huang, S. L.; Saggioro, D.; Michelmann, H.; Malling, H. V.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 57, No. 2, 1978, p. 225-232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic effects of crocidolite asbestos in Chinese hamster lung cells
AU - Huang, S. L.
AU - Saggioro, D.
AU - Michelmann, H.
AU - Malling, H. V.
PY - 1978
Y1 - 1978
N2 - Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.
AB - Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.
UR - http://www.scopus.com/inward/record.url?scp=0018097636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018097636&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(78)90272-5
DO - 10.1016/0027-5107(78)90272-5
M3 - Article
C2 - 661841
AN - SCOPUS:0018097636
VL - 57
SP - 225
EP - 232
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 2
ER -