Genetic effects of crocidolite asbestos in Chinese hamster lung cells

S. L. Huang; D. Saggioro; H. Michelmann; H. V. Malling

doi:10.1016/0027-5107(78)90272-5

Genetic effects of crocidolite asbestos in Chinese hamster lung cells

S. L. Huang, D. Saggioro, H. Michelmann, H. V. Malling

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0027-5107(78)90272-5
Publication status	Published - 1978

ASJC Scopus subject areas

Molecular Biology
Health, Toxicology and Mutagenesis
Medicine(all)

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title = "Genetic effects of crocidolite asbestos in Chinese hamster lung cells",

abstract = "Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.",

author = "Huang, {S. L.} and D. Saggioro and H. Michelmann and Malling, {H. V.}",

year = "1978",

doi = "10.1016/0027-5107(78)90272-5",

language = "English",

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T1 - Genetic effects of crocidolite asbestos in Chinese hamster lung cells

AU - Huang, S. L.

AU - Saggioro, D.

AU - Michelmann, H.

AU - Malling, H. V.

PY - 1978

Y1 - 1978

N2 - Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.

AB - Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.

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JO - Mutation Research

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Genetic effects of crocidolite asbestos in Chinese hamster lung cells

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