Genetic effects of crocidolite asbestos in Chinese hamster lung cells

S. L. Huang, D. Saggioro, H. Michelmann, H. V. Malling

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth. Cell death was directly associated with the phagocytosis of larger fibres as observed with the aid of trypan blue. Watersoluble components of crocidolite did not appear to inhibit cell growth. Chromosomal aberrations were induced by the asbestos. The aberrations were confined mainly to structural aberrations - breaks and fragments. Electron-microscopic preparation indicated that asbestos was readily contained in phagosomes. Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume57
Issue number2
DOIs
Publication statusPublished - 1978

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Crocidolite Asbestos
Asbestos
Cricetulus
Phagocytosis
Lung
Phagosomes
Hypoxanthine
Trypan Blue
Mutagens
Guanine
Growth
Transferases
Chromosome Aberrations
Cultured Cells
Cell Death
Electrons
Mutation
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Genetic effects of crocidolite asbestos in Chinese hamster lung cells. / Huang, S. L.; Saggioro, D.; Michelmann, H.; Malling, H. V.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 57, No. 2, 1978, p. 225-232.

Research output: Contribution to journalArticle

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