Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression

L. De Benedetti, L. Varesco, N. S. Pellegata, L. Losi, V. Gismondi, L. Casarino, S. Sciallero, L. Bonelli, R. Biticchi, A. Bafico, E. Masetti, R. James, A. Heouaine, G. N. Ranzani, H. Aste, G. Ferrara

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-four sporadic colorectal adenomas were analysed for the presence of allelic loss on the short arm of chromosome 17 as well as mutations in the K-ras and p53 genes. Chromosome 17p13 allelic loss was not present in 14 out of 14 informative cases. K-ras mutations were observed in 15 out of 24 cases. A p53 gene mutation (CGC → GAC at codon 245) was detected in two biopsies taken at a four year interval from a recurrent rectal villous adenoma. Both biopsies also contained the same K-ras gene mutation (GGT → GTT at codon 12). The data from the recurrent rectal adenoma provide in vivo evidence that K-ras and p53 heterozygous mutations confer a proliferative advantage but together are not sufficient for malignant transformation.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalAnticancer Research
Volume13
Issue number3
Publication statusPublished - 1993

Keywords

  • Colorectal cancer
  • K-ras
  • p53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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