Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization

Jadwiga Szymanska, Massimo Serra, Björn Skytting, Olle Larsson, Martti Virolainen, Måns Åkerman, Maija Tarkkanen, Riikka Huuhtanen, Piero Picci, Patrizia Bacchini, Sirpa Asko-Seljavaara, Inkeri Elomaa, Sakari Knuutila

Research output: Contribution to journalArticlepeer-review


We used comparative genomic hybridization (CGH) to evaluate DNA sequence copy number changes in 67 synovial sarcomas of both monophasic and biphasic histological subtypes. Changes (mean among aberrant cases; 4.7 aberrations/tumor; range: 1-17), affecting most often entire chromosomes or chromosome arms, were detected in 37 sarcomas (55%). Gains and losses were distributed equally, but different chromosomes were affected with variable frequencies. The most frequent aberrations, each detected in 9-11 of 67 tumors, were gain of 8q and gain at 12q (12q14-15 and 12q23-qter), loss of 13q21-31, and loss of 3p. Other frequent changes (in 7 or 8 cases) included gains at 2p, 1q24-31, and 17q22-qter, and losses at 3cen-q23 and 10q21. High- level amplifications were seen in 7 cases. A total of 16 regions were detected. Two of them, 8p12-qter and 21q21-qter, seen in 4 and 2 tumors, respectively, were recurrent. No aberrations specific to histological subtype were identified. However, genetic changes in the monophasic tumors were more complex and numerous (mean among aberrant cases: 5.3 aberrations/tumor; range: 1-17) than in the biphasic tumors (mean: 2.5 aberrations/tumor; range: 1-5), and high-level amplifications occurred more frequently. All but 1 of the sarcomas showing high-level amplification were of the monophasic subtype. These findings may reflect differences in the pathogenesis and biological behavior of both histological subtypes of synovial sarcoma.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalGenes Chromosomes and Cancer
Issue number3
Publication statusPublished - Nov 1998

ASJC Scopus subject areas

  • Cancer Research
  • Genetics


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