Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

Pierleone Lucatelli; Corrado Fagnani; Adam Domonkos Tarnoki; David Laszlo Tarnoki; Beatrice Sacconi; Bence Fejer; Maria Antonietta Stazi; Miriam Salemi; Carlo Cirelli; Alessandro d'Adamo; Fabrizio Fanelli; Carlo Catalano; Pal Maurovich-Horvat; Adam L Jermendy; Gyorgy Jermendy; Bela Merkely; Andrea A Molnar; Giacomo Pucci; Giuseppe Schillaci; Filippo Farina; Giorgio Meneghetti; Claudio Baracchini; Emanuela Medda

doi:10.1007/s10554-017-1256-2

Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

Pierleone Lucatelli, Corrado Fagnani, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Beatrice Sacconi, Bence Fejer, Maria Antonietta Stazi, Miriam Salemi, Carlo Cirelli, Alessandro d'Adamo, Fabrizio Fanelli, Carlo Catalano, Pal Maurovich-Horvat, Adam L Jermendy, Gyorgy Jermendy, Bela Merkely, Andrea A Molnar, Giacomo Pucci, Giuseppe Schillaci, Filippo FarinaGiorgio Meneghetti, Claudio Baracchini, Emanuela Medda

Istituto Superiore di Sanita'

Research output: Contribution to journal › Article › peer-review

Abstract

To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.

Original language	English
Pages (from-to)	531-541
Number of pages	11
Journal	International Journal of Cardiovascular Imaging
Volume	34
Issue number	4
DOIs	https://doi.org/10.1007/s10554-017-1256-2
Publication status	Published - Apr 2018

Keywords

Adult
Aged
Carotid Arteries/diagnostic imaging
Carotid Artery Diseases/diagnostic imaging
Carotid Intima-Media Thickness
Female
Femoral Artery/diagnostic imaging
Gene-Environment Interaction
Humans
Hungary
Italy
Male
Middle Aged
Peripheral Arterial Disease/diagnostic imaging
Plaque, Atherosclerotic
Risk Factors
Twins, Dizygotic/genetics
Twins, Monozygotic/genetics
Ultrasonography, Doppler, Color
Young Adult

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10.1007/s10554-017-1256-2

Cite this

Lucatelli, P., Fagnani, C., Tarnoki, A. D., Tarnoki, D. L., Sacconi, B., Fejer, B., Stazi, M. A., Salemi, M., Cirelli, C., d'Adamo, A., Fanelli, F., Catalano, C., Maurovich-Horvat, P., Jermendy, A. L., Jermendy, G., Merkely, B., Molnar, A. A., Pucci, G., Schillaci, G., ... Medda, E. (2018). Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study. International Journal of Cardiovascular Imaging, 34(4), 531-541. https://doi.org/10.1007/s10554-017-1256-2

Lucatelli, P, Fagnani, C, Tarnoki, AD, Tarnoki, DL, Sacconi, B, Fejer, B, Stazi, MA, Salemi, M, Cirelli, C, d'Adamo, A, Fanelli, F, Catalano, C, Maurovich-Horvat, P, Jermendy, AL, Jermendy, G, Merkely, B, Molnar, AA, Pucci, G, Schillaci, G, Farina, F, Meneghetti, G, Baracchini, C & Medda, E 2018, 'Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study', International Journal of Cardiovascular Imaging, vol. 34, no. 4, pp. 531-541. https://doi.org/10.1007/s10554-017-1256-2

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title = "Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study",

abstract = "To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.",

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author = "Pierleone Lucatelli and Corrado Fagnani and Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Beatrice Sacconi and Bence Fejer and Stazi, {Maria Antonietta} and Miriam Salemi and Carlo Cirelli and Alessandro d'Adamo and Fabrizio Fanelli and Carlo Catalano and Pal Maurovich-Horvat and Jermendy, {Adam L} and Gyorgy Jermendy and Bela Merkely and Molnar, {Andrea A} and Giacomo Pucci and Giuseppe Schillaci and Filippo Farina and Giorgio Meneghetti and Claudio Baracchini and Emanuela Medda",

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doi = "10.1007/s10554-017-1256-2",

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T1 - Genetic influence on femoral plaque and its relationship with carotid plaque

T2 - an international twin study

AU - Lucatelli, Pierleone

AU - Fagnani, Corrado

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Sacconi, Beatrice

AU - Fejer, Bence

AU - Stazi, Maria Antonietta

AU - Salemi, Miriam

AU - Cirelli, Carlo

AU - d'Adamo, Alessandro

AU - Fanelli, Fabrizio

AU - Catalano, Carlo

AU - Maurovich-Horvat, Pal

AU - Jermendy, Adam L

AU - Jermendy, Gyorgy

AU - Merkely, Bela

AU - Molnar, Andrea A

AU - Pucci, Giacomo

AU - Schillaci, Giuseppe

AU - Farina, Filippo

AU - Meneghetti, Giorgio

AU - Baracchini, Claudio

AU - Medda, Emanuela

PY - 2018/4

Y1 - 2018/4

N2 - To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.

AB - To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.

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KW - Aged

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KW - Carotid Artery Diseases/diagnostic imaging

KW - Carotid Intima-Media Thickness

KW - Female

KW - Femoral Artery/diagnostic imaging

KW - Gene-Environment Interaction

KW - Humans

KW - Hungary

KW - Italy

KW - Male

KW - Middle Aged

KW - Peripheral Arterial Disease/diagnostic imaging

KW - Plaque, Atherosclerotic

KW - Risk Factors

KW - Twins, Dizygotic/genetics

KW - Twins, Monozygotic/genetics

KW - Ultrasonography, Doppler, Color

KW - Young Adult

U2 - 10.1007/s10554-017-1256-2

DO - 10.1007/s10554-017-1256-2

M3 - Article

C2 - 29022127

VL - 34

SP - 531

EP - 541

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 4

ER -

Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

Abstract

Keywords

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