TY - JOUR
T1 - Genetic influence on femoral plaque and its relationship with carotid plaque
T2 - an international twin study
AU - Lucatelli, Pierleone
AU - Fagnani, Corrado
AU - Tarnoki, Adam Domonkos
AU - Tarnoki, David Laszlo
AU - Sacconi, Beatrice
AU - Fejer, Bence
AU - Stazi, Maria Antonietta
AU - Salemi, Miriam
AU - Cirelli, Carlo
AU - d'Adamo, Alessandro
AU - Fanelli, Fabrizio
AU - Catalano, Carlo
AU - Maurovich-Horvat, Pal
AU - Jermendy, Adam L
AU - Jermendy, Gyorgy
AU - Merkely, Bela
AU - Molnar, Andrea A
AU - Pucci, Giacomo
AU - Schillaci, Giuseppe
AU - Farina, Filippo
AU - Meneghetti, Giorgio
AU - Baracchini, Claudio
AU - Medda, Emanuela
PY - 2018/4
Y1 - 2018/4
N2 - To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.
AB - To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.
KW - Adult
KW - Aged
KW - Carotid Arteries/diagnostic imaging
KW - Carotid Artery Diseases/diagnostic imaging
KW - Carotid Intima-Media Thickness
KW - Female
KW - Femoral Artery/diagnostic imaging
KW - Gene-Environment Interaction
KW - Humans
KW - Hungary
KW - Italy
KW - Male
KW - Middle Aged
KW - Peripheral Arterial Disease/diagnostic imaging
KW - Plaque, Atherosclerotic
KW - Risk Factors
KW - Twins, Dizygotic/genetics
KW - Twins, Monozygotic/genetics
KW - Ultrasonography, Doppler, Color
KW - Young Adult
U2 - 10.1007/s10554-017-1256-2
DO - 10.1007/s10554-017-1256-2
M3 - Article
C2 - 29022127
VL - 34
SP - 531
EP - 541
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 4
ER -