Genetic instability and increased mutational load: Which diagnostic tool best direct patients with cancer to immunotherapy?

Giuseppe Palmieri, Maria Colombino, Antonio Cossu, Antonio Marchetti, Gerardo Botti, Paolo A. Ascierto

Research output: Contribution to journalComment/debate

Abstract

The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.

Original languageEnglish
Article number17
JournalJournal of Translational Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 21 2017

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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