Genetic instability in superficial bladder cancer and adjacent mucosa: An interphase cytogenetic study

Anna Maria Cianciulli, Costantino Leonardo, Fiorella Guadagni, Raffaella Marzano, Francesco Iori, Cosimo De Nunzio, Giorgio Franco, Roberta Merola, Cesare Laurenti

Research output: Contribution to journalArticle

Abstract

A systematic analysis of both tumors and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. In this study we investigated chromosome 1, 7, 9, and 17 aneusomy in 25 superficial papillary carcinomas and in 51 tissue samples taken from sites of macroscopically uninvolved urothelium surrounding the tumors, using the fluorescence in situ hybridization method. Our data demonstrated a close genetic relationship between all examined tumors and normal-appearing mucosa. Numeric aberrations of chromosomes 1, 7, 9, and 17 were found to exhibit similar patterns in all analyzed specimens, although with different frequencies. HUM PATHOL 34:

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalHuman Pathology
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Keywords

  • Bladder cancer
  • Chromosomes 1, 7, 9, and 17
  • Genetic instability

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cianciulli, A. M., Leonardo, C., Guadagni, F., Marzano, R., Iori, F., De Nunzio, C., Franco, G., Merola, R., & Laurenti, C. (2003). Genetic instability in superficial bladder cancer and adjacent mucosa: An interphase cytogenetic study. Human Pathology, 34(3), 214-221. https://doi.org/10.1053/hupa.2003.30