TY - JOUR
T1 - Genetic instability in superficial bladder cancer and adjacent mucosa
T2 - An interphase cytogenetic study
AU - Cianciulli, Anna Maria
AU - Leonardo, Costantino
AU - Guadagni, Fiorella
AU - Marzano, Raffaella
AU - Iori, Francesco
AU - De Nunzio, Cosimo
AU - Franco, Giorgio
AU - Merola, Roberta
AU - Laurenti, Cesare
PY - 2003/3/1
Y1 - 2003/3/1
N2 - A systematic analysis of both tumors and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. In this study we investigated chromosome 1, 7, 9, and 17 aneusomy in 25 superficial papillary carcinomas and in 51 tissue samples taken from sites of macroscopically uninvolved urothelium surrounding the tumors, using the fluorescence in situ hybridization method. Our data demonstrated a close genetic relationship between all examined tumors and normal-appearing mucosa. Numeric aberrations of chromosomes 1, 7, 9, and 17 were found to exhibit similar patterns in all analyzed specimens, although with different frequencies. HUM PATHOL 34:
AB - A systematic analysis of both tumors and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. In this study we investigated chromosome 1, 7, 9, and 17 aneusomy in 25 superficial papillary carcinomas and in 51 tissue samples taken from sites of macroscopically uninvolved urothelium surrounding the tumors, using the fluorescence in situ hybridization method. Our data demonstrated a close genetic relationship between all examined tumors and normal-appearing mucosa. Numeric aberrations of chromosomes 1, 7, 9, and 17 were found to exhibit similar patterns in all analyzed specimens, although with different frequencies. HUM PATHOL 34:
KW - Bladder cancer
KW - Chromosomes 1, 7, 9, and 17
KW - Genetic instability
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U2 - 10.1053/hupa.2003.30
DO - 10.1053/hupa.2003.30
M3 - Article
C2 - 12673554
AN - SCOPUS:0037343366
VL - 34
SP - 214
EP - 221
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 3
ER -