Abstract
Rationale: Relapse to drug use after periods of forced or self-imposed abstinence is a central problem in the treatment of addiction; therefore, identification of factors modulating the risk to relapse is a relevant goal of preclinical research. Objectives: These experiments evaluated the influence of the amount of drug experienced, the duration of drug withdrawal, and individual liability on the propensity to cocaine-induced reinstatement of conditioned place preference (CPP). Materials and methods: Mice from the inbred strains C57BL/6J and DBA/2J were trained for CPP with a high (20 mg/kg) or low (5 mg/kg) effective dose of cocaine. After CPP testing, all groups underwent extinction. Twenty-four hours after the extinction test, mice were challenged with saline, a cocaine dose unable to induce CPP (2.5 mg/kg) or an intermediate effective dose (10 mg/kg), and tested for CPP reinstatement. Additional groups of mice trained with the low cocaine dose were left undisturbed for 8 days after extinction test (long withdrawal), retested for extinction, and evaluated for prime-induced reinstatement (0, 2.5, 10 mg/kg of cocaine). Results: Mice trained with the high cocaine dose, but not with the low one, showed prime-induced reinstatement 24 h after the extinction test; DBA/2J mice trained with the low dose showed reinstatement after long withdrawal. Conclusions: These results indicate that reinstatement of CPP by cocaine prime depends on the amount of drug experienced and on an interaction between individual liability and duration of drug abstinence and suggest that the risk to relapse into drug seeking is not prevented by moderated drug consumption.
| Original language | English |
|---|---|
| Pages (from-to) | 287-296 |
| Number of pages | 10 |
| Journal | Psychopharmacology |
| Volume | 198 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Addiction
- Cocaine
- Drug seeking
- Inbred strain
- Incentive
- Individual differences
- Liability
- Mice
- Place conditioning
- Reinstatement
ASJC Scopus subject areas
- Pharmacology
Cite this
Genetic liability increases propensity to prime-induced reinstatement of conditioned place preference in mice exposed to low cocaine. / Orsini, Cristina; Bonito-Oliva, Alessandra; Conversi, David; Cabib, Simona.
In: Psychopharmacology, Vol. 198, No. 2, 06.2008, p. 287-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic liability increases propensity to prime-induced reinstatement of conditioned place preference in mice exposed to low cocaine
AU - Orsini, Cristina
AU - Bonito-Oliva, Alessandra
AU - Conversi, David
AU - Cabib, Simona
PY - 2008/6
Y1 - 2008/6
N2 - Rationale: Relapse to drug use after periods of forced or self-imposed abstinence is a central problem in the treatment of addiction; therefore, identification of factors modulating the risk to relapse is a relevant goal of preclinical research. Objectives: These experiments evaluated the influence of the amount of drug experienced, the duration of drug withdrawal, and individual liability on the propensity to cocaine-induced reinstatement of conditioned place preference (CPP). Materials and methods: Mice from the inbred strains C57BL/6J and DBA/2J were trained for CPP with a high (20 mg/kg) or low (5 mg/kg) effective dose of cocaine. After CPP testing, all groups underwent extinction. Twenty-four hours after the extinction test, mice were challenged with saline, a cocaine dose unable to induce CPP (2.5 mg/kg) or an intermediate effective dose (10 mg/kg), and tested for CPP reinstatement. Additional groups of mice trained with the low cocaine dose were left undisturbed for 8 days after extinction test (long withdrawal), retested for extinction, and evaluated for prime-induced reinstatement (0, 2.5, 10 mg/kg of cocaine). Results: Mice trained with the high cocaine dose, but not with the low one, showed prime-induced reinstatement 24 h after the extinction test; DBA/2J mice trained with the low dose showed reinstatement after long withdrawal. Conclusions: These results indicate that reinstatement of CPP by cocaine prime depends on the amount of drug experienced and on an interaction between individual liability and duration of drug abstinence and suggest that the risk to relapse into drug seeking is not prevented by moderated drug consumption.
AB - Rationale: Relapse to drug use after periods of forced or self-imposed abstinence is a central problem in the treatment of addiction; therefore, identification of factors modulating the risk to relapse is a relevant goal of preclinical research. Objectives: These experiments evaluated the influence of the amount of drug experienced, the duration of drug withdrawal, and individual liability on the propensity to cocaine-induced reinstatement of conditioned place preference (CPP). Materials and methods: Mice from the inbred strains C57BL/6J and DBA/2J were trained for CPP with a high (20 mg/kg) or low (5 mg/kg) effective dose of cocaine. After CPP testing, all groups underwent extinction. Twenty-four hours after the extinction test, mice were challenged with saline, a cocaine dose unable to induce CPP (2.5 mg/kg) or an intermediate effective dose (10 mg/kg), and tested for CPP reinstatement. Additional groups of mice trained with the low cocaine dose were left undisturbed for 8 days after extinction test (long withdrawal), retested for extinction, and evaluated for prime-induced reinstatement (0, 2.5, 10 mg/kg of cocaine). Results: Mice trained with the high cocaine dose, but not with the low one, showed prime-induced reinstatement 24 h after the extinction test; DBA/2J mice trained with the low dose showed reinstatement after long withdrawal. Conclusions: These results indicate that reinstatement of CPP by cocaine prime depends on the amount of drug experienced and on an interaction between individual liability and duration of drug abstinence and suggest that the risk to relapse into drug seeking is not prevented by moderated drug consumption.
KW - Addiction
KW - Cocaine
KW - Drug seeking
KW - Inbred strain
KW - Incentive
KW - Individual differences
KW - Liability
KW - Mice
KW - Place conditioning
KW - Reinstatement
UR - http://www.scopus.com/inward/record.url?scp=43049113134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049113134&partnerID=8YFLogxK
U2 - 10.1007/s00213-008-1137-4
DO - 10.1007/s00213-008-1137-4
M3 - Article
VL - 198
SP - 287
EP - 296
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -