Genetic linkage analysis and presymptomatic testing in Huntington's disease. First report in Italy.

L. Di Maio, S. Boiano, F. Squitieri, G. Napolitano, S. Cocozza, G. Campanella, G. Battistuzzi

Research output: Contribution to journalArticle

Abstract

Since 1979 data about Huntington's Disease (HD) in Campania, a region of Southern Italy, has been collecting. The prevalence of HD in this sample is 30.3 x 10(-6) (115 pedigrees, 1470 individuals). Mean age at onset was 38.67 years and the juvenile (onset before 20 years) accounted for 5.8%. Genetic linkage analysis in 4 unrelated pedigrees with D4S10 and D4S95 DNA probes has been performed. The absence of genetic heterogeneity--already proposed in a cooperative study for one pedigree--has been confirmed in this study.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalActa Neurologica
Volume14
Issue number4-6
Publication statusPublished - Aug 1992

ASJC Scopus subject areas

  • Clinical Neurology

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    Di Maio, L., Boiano, S., Squitieri, F., Napolitano, G., Cocozza, S., Campanella, G., & Battistuzzi, G. (1992). Genetic linkage analysis and presymptomatic testing in Huntington's disease. First report in Italy. Acta Neurologica, 14(4-6), 524-529.