Genetic mapping and expression analysis of the murine DNA ligase I gene

M. Gariboldi, A. Montecucco, A. Columbano, M. Ledda-Columbano, E. Savini, G. Manenti, M. A. Pierotti, T. A. Dragani

Research output: Contribution to journalArticle

Abstract

We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalMolecular Carcinogenesis
Volume14
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Liver Regeneration
Chromosomes, Human, Pair 7
Carbon Tetrachloride
Human Chromosomes
Hepatectomy
Mitogens
Genes
Cell Proliferation
Genome
Liver
DNA Ligase ATP
1,4-bis(2-(3,5-dichloropyridyloxy))benzene

Keywords

  • Chromosome mapping
  • DNA repair
  • Inbred C3H mice
  • Liver regeneration
  • Mitogens

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

Cite this

Genetic mapping and expression analysis of the murine DNA ligase I gene. / Gariboldi, M.; Montecucco, A.; Columbano, A.; Ledda-Columbano, M.; Savini, E.; Manenti, G.; Pierotti, M. A.; Dragani, T. A.

In: Molecular Carcinogenesis, Vol. 14, No. 2, 1995, p. 71-74.

Research output: Contribution to journalArticle

Gariboldi, M, Montecucco, A, Columbano, A, Ledda-Columbano, M, Savini, E, Manenti, G, Pierotti, MA & Dragani, TA 1995, 'Genetic mapping and expression analysis of the murine DNA ligase I gene', Molecular Carcinogenesis, vol. 14, no. 2, pp. 71-74. https://doi.org/10.1002/mc.2940140202
Gariboldi, M. ; Montecucco, A. ; Columbano, A. ; Ledda-Columbano, M. ; Savini, E. ; Manenti, G. ; Pierotti, M. A. ; Dragani, T. A. / Genetic mapping and expression analysis of the murine DNA ligase I gene. In: Molecular Carcinogenesis. 1995 ; Vol. 14, No. 2. pp. 71-74.
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