Genetic mapping and expression analysis of the murine DNA ligase I gene

M. Gariboldi, A. Montecucco, A. Columbano, M. Ledda-Columbano, E. Savini, G. Manenti, M. A. Pierotti, T. A. Dragani

Research output: Contribution to journalArticle

Abstract

We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalMolecular Carcinogenesis
Volume14
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • Chromosome mapping
  • DNA repair
  • Inbred C3H mice
  • Liver regeneration
  • Mitogens

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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