Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression

Giacomo Manenti, Manuela Gariboldi, Antonio Fiorino, Nicola Zanesi, Marco A. Pierotti, Tommaso A. Dragani

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease. In the present report, we have crossed the BALB/c with the SWR/J strain and performed whole-genome scanning for loci affecting lung tumor development in their F2 progeny. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major locus affecting predisposition to lung cancer in mice. On distal chromosome 18 and on centromere of chromosome 6, we have mapped two pulmonary adenoma resistance loci (Par2 and Par4, respectively), which reduce lung tumor multiplicity strongly, up to 15- fold. Par2 and Par4, however, do not affect lung tumor size, which is instead controlled by an additional locus that we have mapped on the central region of chromosome 4. We designated this locus as 'pulmonary adenoma progression 1' (Papg1), because it specifically modifies lung tumor size but not multiplicity. The present results, therefore, provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.

Original languageEnglish
Pages (from-to)4164-4166
Number of pages3
JournalCancer Research
Volume57
Issue number19
Publication statusPublished - Oct 1 1997

Fingerprint

Lung Neoplasms
Lung
Neoplasms
Adenoma
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 4
Inborn Genetic Diseases
Chromosomes, Human, Pair 6
Inbred Strains Mice
Centromere
Dissection
Carcinogenesis
Genome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression. / Manenti, Giacomo; Gariboldi, Manuela; Fiorino, Antonio; Zanesi, Nicola; Pierotti, Marco A.; Dragani, Tommaso A.

In: Cancer Research, Vol. 57, No. 19, 01.10.1997, p. 4164-4166.

Research output: Contribution to journalArticle

@article{7481553bbf0d4788b96f6d0da3e8b6ba,
title = "Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression",
abstract = "Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease. In the present report, we have crossed the BALB/c with the SWR/J strain and performed whole-genome scanning for loci affecting lung tumor development in their F2 progeny. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major locus affecting predisposition to lung cancer in mice. On distal chromosome 18 and on centromere of chromosome 6, we have mapped two pulmonary adenoma resistance loci (Par2 and Par4, respectively), which reduce lung tumor multiplicity strongly, up to 15- fold. Par2 and Par4, however, do not affect lung tumor size, which is instead controlled by an additional locus that we have mapped on the central region of chromosome 4. We designated this locus as 'pulmonary adenoma progression 1' (Papg1), because it specifically modifies lung tumor size but not multiplicity. The present results, therefore, provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.",
author = "Giacomo Manenti and Manuela Gariboldi and Antonio Fiorino and Nicola Zanesi and Pierotti, {Marco A.} and Dragani, {Tommaso A.}",
year = "1997",
month = "10",
day = "1",
language = "English",
volume = "57",
pages = "4164--4166",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "19",

}

TY - JOUR

T1 - Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression

AU - Manenti, Giacomo

AU - Gariboldi, Manuela

AU - Fiorino, Antonio

AU - Zanesi, Nicola

AU - Pierotti, Marco A.

AU - Dragani, Tommaso A.

PY - 1997/10/1

Y1 - 1997/10/1

N2 - Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease. In the present report, we have crossed the BALB/c with the SWR/J strain and performed whole-genome scanning for loci affecting lung tumor development in their F2 progeny. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major locus affecting predisposition to lung cancer in mice. On distal chromosome 18 and on centromere of chromosome 6, we have mapped two pulmonary adenoma resistance loci (Par2 and Par4, respectively), which reduce lung tumor multiplicity strongly, up to 15- fold. Par2 and Par4, however, do not affect lung tumor size, which is instead controlled by an additional locus that we have mapped on the central region of chromosome 4. We designated this locus as 'pulmonary adenoma progression 1' (Papg1), because it specifically modifies lung tumor size but not multiplicity. The present results, therefore, provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.

AB - Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease. In the present report, we have crossed the BALB/c with the SWR/J strain and performed whole-genome scanning for loci affecting lung tumor development in their F2 progeny. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major locus affecting predisposition to lung cancer in mice. On distal chromosome 18 and on centromere of chromosome 6, we have mapped two pulmonary adenoma resistance loci (Par2 and Par4, respectively), which reduce lung tumor multiplicity strongly, up to 15- fold. Par2 and Par4, however, do not affect lung tumor size, which is instead controlled by an additional locus that we have mapped on the central region of chromosome 4. We designated this locus as 'pulmonary adenoma progression 1' (Papg1), because it specifically modifies lung tumor size but not multiplicity. The present results, therefore, provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=0030818561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030818561&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 4164

EP - 4166

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 19

ER -