Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)414-430
Number of pages17
JournalNature Genetics
Volume51
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • amyloid beta protein
  • lipid
  • tau protein
  • aged
  • Alzheimer disease
  • case control study
  • female
  • gene locus
  • genetic predisposition
  • genetic screening
  • genetics
  • genome-wide association study
  • haplotype
  • human
  • immunity
  • lipid metabolism
  • male
  • meta analysis
  • procedures
  • Aged
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Case-Control Studies
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Genome-Wide Association Study
  • Haplotypes
  • Humans
  • Immunity
  • Lipid Metabolism
  • Lipids
  • Male
  • tau Proteins

Cite this

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) (2019). Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics, 51(3), 414-430. https://doi.org/10.1038/s41588-019-0358-2

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. / Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES).

In: Nature Genetics, Vol. 51, No. 3, 2019, p. 414-430.

Research output: Contribution to journalArticle

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) 2019, 'Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing', Nature Genetics, vol. 51, no. 3, pp. 414-430. https://doi.org/10.1038/s41588-019-0358-2
Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES). Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 2019;51(3):414-430. https://doi.org/10.1038/s41588-019-0358-2
Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES). / Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. In: Nature Genetics. 2019 ; Vol. 51, No. 3. pp. 414-430.
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AU - Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s DiseaseInitiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environ

AU - Kunkle, B.W.

AU - Grenier-Boley, B.

AU - Sims, R.

AU - Bis, J.C.

AU - Damotte, V.

AU - Naj, A.C.

AU - Boland, A.

AU - Vronskaya, M.

AU - van der Lee, S.J.

AU - Amlie-Wolf, A.

AU - Bellenguez, C.

AU - Frizatti, A.

AU - Chouraki, V.

AU - Martin, E.R.

AU - Sleegers, K.

AU - Badarinarayan, N.

AU - Jakobsdottir, J.

AU - Hamilton-Nelson, K.L.

AU - Moreno-Grau, S.

AU - Olaso, R.

AU - Raybould, R.

AU - Chen, Y.

AU - Kuzma, A.B.

AU - Hiltunen, M.

AU - Morgan, T.

AU - Ahmad, S.

AU - Vardarajan, B.N.

AU - Epelbaum, J.

AU - Hoffmann, P.

AU - Boada, M.

AU - Beecham, G.W.

AU - Hughes, J.T.

AU - Galimberti, D.

AU - Scarpini, E.

AU - Salani, F.

AU - Ciaramella, A.

AU - Mancuso, M.

AU - Russo, G.

AU - Daniele, A.

AU - Sorbi, S.

AU - Sacchinelli, E.

AU - Spalletta, G.

AU - Caltagirone, C.

AU - Bossù, P.

AU - Orfei, M.D.

AU - Gallo, M.

AU - Cuccaro, M.L.

AU - Spina, S.

AU - Pilotto, A.

AU - Bosco, P.

N1 - Export Date: 26 August 2019 CODEN: NGENE Correspondence Address: Kunkle, B.W.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of MedicineUnited States; email: bkunkle@miami.edu

PY - 2019

Y1 - 2019

KW - amyloid beta protein

KW - lipid

KW - tau protein

KW - aged

KW - Alzheimer disease

KW - case control study

KW - female

KW - gene locus

KW - genetic predisposition

KW - genetic screening

KW - genetics

KW - genome-wide association study

KW - haplotype

KW - human

KW - immunity

KW - lipid metabolism

KW - male

KW - meta analysis

KW - procedures

KW - Aged

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Case-Control Studies

KW - Female

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genome-Wide Association Study

KW - Haplotypes

KW - Humans

KW - Immunity

KW - Lipid Metabolism

KW - Lipids

KW - Male

KW - tau Proteins

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DO - 10.1038/s41588-019-0358-2

M3 - Article

VL - 51

SP - 414

EP - 430

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -